Development of small animal infection model for evaluating barrier properties of the epidermal seal against infection around the percutaneous implant systems – a pilot study

Statement of Purpose: Percutaneous osseointegrated prosthetic docking systems are increasingly used to rehabilitate patients with limb loss. One potential cause of failure of these devices is epithelial downgrowth, which is attributed to the body’s attempt to repair the breached continuity of the epidermis due to the presence of a percutaneous post [1]. This results in the formation of a sinus tract extending along the implant surface. Bacteria can colonize this space and potentially infect the host if the interface does not prevent bacterial ingress. This may in turn lead to deep, opportunistic infection and implant failure. Currently, in order to prevent downgrowth, various implant materials and coatings are being investigated. However, there are no small animal infection models that can be used to determine the efficacy of these materials to mitigate infection. Thus, the current study was undertaken in an attempt to develop a relevant infection model.