@article{7d7ae3f983bb4cbe935c20bb59411aa7,
title = "Differences in Self-Reported Food Allergy and Food-Associated Anaphylaxis by Race and Ethnicity Among SAPPHIRE Cohort Participants",
abstract = "Background: Although food allergies are considered common, relatively little is known about disparities in food allergy by race in the United States. Objective: To evaluate differences in reported food allergy and food-associated anaphylaxis among individuals enrolled in a longitudinal cohort study from metropolitan Detroit, Michigan. Methods: Participants in the Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE) were asked about food allergies, including the inciting food and associated symptoms. Individuals were considered to have food-associated anaphylaxis if symptoms coincided with established clinical criteria. Logistic regression was used to assess whether race difference persisted after adjusting for and stratifying by potential confounders. African genetic ancestry was individually estimated among African American SAPPHIRE participants to assess whether ancestry was associated with food allergy. Results: Within the SAPPHIRE cohort, African American participants were significantly more likely to report food allergy (26.1% vs 17%; P = 3.47 × 10−18) and have food-associated anaphylactic symptoms (12.7% vs 7%; P = 4.65 × 10−14) when compared with European American participants. Allergy to seafood accounted for the largest difference (13.1% vs 4.6%; P = 1.38 × 10−31). Differences in food allergy by race persisted after adjusting for potential confounders including asthma status. Among African American participants, the proportion of African ancestry was not associated with any outcome evaluated. Conclusion: Compared with European Americans, African Americans appear to be at higher risk for developing food allergy and food-associated anaphylaxis, particularly with regard to seafood allergy. The lack of association with genetic ancestry suggests that socioenvironmental determinants may play a role in these disparities.",
keywords = "Anaphylaxis, Food allergy, Genetic ancestry, Health status disparities",
author = "Shujie Xiao and Neha Sahasrabudhe and Mao Yang and Donglei Hu and Patrick Sleiman and Samantha Hochstadt and Whitney Cabral and Frank Gilliland and Gauderman, {W. James} and Fernando Martinez and Hakon Hakonarson and Rajesh Kumar and Burchard, {Esteban G.} and Williams, {L. Keoki}",
note = "Funding Information: Conflicts of interest: F. Martinez reports funding from the NHLBI, NIAID, NIEHS, and Office of the Director , NIH, unrelated to the current work. H. Hakonarson reports funding from NHLBI and Children{\textquoteright}s Hospital of Philadelphia related to the current work. R. Kumar reports NIH funding, consultant work for Regeneron and honoraria from Indiana University and the Hospital for Sick Children (Toronto, Canada), unrelated to the current work. E. G. Burchard reports funding from the Sandler Family Foundation, the RWJF Amos Medical Faculty Development Program, and the NHLBI, the NIMHD, the NIGMS, NHGRI, and the NIEHS of the NIH related to the current work. L. K. Williams reports funding from the NIAID, the NHLBI, and the NIDDK related to the current work. The rest of the authors declare that they have no relevant conflicts of interest. Funding Information: Whole genome sequencing (WGS) for the Trans-Omics in Precision Medicine (TOPMed) program was supported by the National Heart, Lung, and Blood Institute (NHLBI). WGS for “NHLBI TOPMed: Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity” (phs001467.v1.p1) was performed at University of Washington's Northwest Genome Center (HHSN268201600032I). Centralized read mapping and genotype calling along with variant quality metrics and filtering were provided by the TOPMed Informatics Research Center (3R01HL-117626-02S1; contract HHSN268201800002I). Phenotype harmonization, data management, sample-identity QC, and general study coordination were provided by the TOPMed Data Coordinating Center (3R01HL-120393-02S1; contract HHSN268201800001I). This work was supported by the Fund for Henry Ford Hospital (L. K. Williams); the American Asthma Foundation (E. G. Burchard, L. K. Williams); the Robert Wood Johnson Foundation Harold Amos Medical Faculty Development Program (E. G. Burchard); and the following institutes of the National Institutes of Health (NIH): National Institute of Allergy and Infectious Diseases (NIAID: R56AI165903 to E. G. Burchard; R01AI079139, R01AI061774, and R56AI165903 to L. K. Williams), the National Heart Lung and Blood Institute (NHLBI: R01HL117004, R01HL128439, R01HL135156, R01HL141992, R01HL155024, and X01HL134589 to E. G. Burchard; R01HL079055, R01HL118267, R01HL141845, and X01HL134589 to L. K. Williams), the National Institute on Minority Health and Health Disparities (NIMHD: R01MD010443 and R56MD013312 to E. G. Burchard), the National Institute of General Medical Sciences (NIGMS: T32GM007546 to E. G. Burchard), the National Institute of Environmental Health Sciences (NIEHS: R01ES015794 and R21ES024844 to E. G. Burchard), the National Human Genome Research Institute (NHGRI: U01HG009080 to E. G. Burchard), and the National Institute of Diabetes and Digestive and Kidney diseases (NIDDK: R01DK064695 and R01DK113003 to L. K. Williams).Conflicts of interest: F. Martinez reports funding from the NHLBI, NIAID, NIEHS, and Office of the Director, NIH, unrelated to the current work. H. Hakonarson reports funding from NHLBI and Children's Hospital of Philadelphia related to the current work. R. Kumar reports NIH funding, consultant work for Regeneron and honoraria from Indiana University and the Hospital for Sick Children (Toronto, Canada), unrelated to the current work. E. G. Burchard reports funding from the Sandler Family Foundation, the RWJF Amos Medical Faculty Development Program, and the NHLBI, the NIMHD, the NIGMS, NHGRI, and the NIEHS of the NIH related to the current work. L. K. Williams reports funding from the NIAID, the NHLBI, and the NIDDK related to the current work. The rest of the authors declare that they have no relevant conflicts of interest. Funding Information: Whole genome sequencing (WGS) for the Trans-Omics in Precision Medicine (TOPMed) program was supported by the National Heart, Lung, and Blood Institute (NHLBI). WGS for “NHLBI TOPMed: Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity” (phs001467.v1.p1) was performed at University of Washington{\textquoteright}s Northwest Genome Center (HHSN268201600032I). Centralized read mapping and genotype calling along with variant quality metrics and filtering were provided by the TOPMed Informatics Research Center (3R01HL-117626-02S1; contract HHSN268201800002I). Phenotype harmonization, data management, sample-identity QC, and general study coordination were provided by the TOPMed Data Coordinating Center (3R01HL-120393-02S1; contract HHSN268201800001I). This work was supported by the Fund for Henry Ford Hospital (L. K. Williams); the American Asthma Foundation (E. G. Burchard, L. K. Williams); the Robert Wood Johnson Foundation Harold Amos Medical Faculty Development Program (E. G. Burchard); and the following institutes of the National Institutes of Health (NIH): National Institute of Allergy and Infectious Diseases (NIAID: R56AI165903 to E. G. Burchard; R01AI079139, R01AI061774, and R56AI165903 to L. K. Williams), the National Heart Lung and Blood Institute (NHLBI: R01HL117004, R01HL128439, R01HL135156, R01HL141992, R01HL155024, and X01HL134589 to E. G. Burchard; R01HL079055, R01HL118267, R01HL141845, and X01HL134589 to L. K. Williams), the National Institute on Minority Health and Health Disparities (NIMHD: R01MD010443 and R56MD013312 to E. G. Burchard), the National Institute of General Medical Sciences (NIGMS: T32GM007546 to E. G. Burchard), the National Institute of Environmental Health Sciences (NIEHS: R01ES015794 and R21ES024844 to E. G. Burchard), the National Human Genome Research Institute (NHGRI: U01HG009080 to E. G. Burchard), and the National Institute of Diabetes and Digestive and Kidney diseases (NIDDK: R01DK064695 and R01DK113003 to L. K. Williams). Publisher Copyright: {\textcopyright} 2022 American Academy of Allergy, Asthma & Immunology",
year = "2023",
month = apr,
doi = "https://doi.org/10.1016/j.jaip.2022.10.048",
language = "English (US)",
volume = "11",
pages = "1123--1133.e11",
journal = "Journal of Allergy and Clinical Immunology: In Practice",
issn = "2213-2198",
publisher = "Elsevier",
number = "4",
}