Abstract
We describe the identification of a novel picornavirus recovered from the fecal specimen of a child in The Gambia, provisionally named rosavirus 2. Comparison of the rosavirus 2 complete genome demonstrated 71.9% nucleotide identity to its closest relative rosavirus M-7, an unclassified picornavirus identified from rodent fecal material. A unique RNA structure was predicted in the 3' UTR of rosavirus 2 that was conserved with rosavirus M-7 and cadiciviruses. We detected rosavirus 2 in four pediatric fecal specimens (0.55% prevalence) in a Gambian diarrheal case-control cohort, but we did not detect it in a panel of 634 pediatric diarrheal stool specimens from the USA. There was no statistical evidence that rosavirus 2 was associated with diarrheal cases. This study broadens our understanding of unknown viruses present in children in developing country settings.
Original language | English (US) |
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Pages (from-to) | 25-33 |
Number of pages | 9 |
Journal | Virology |
Volume | 454-455 |
Issue number | 1 |
DOIs | |
State | Published - Apr 2014 |
Externally published | Yes |
Keywords
- Developing country
- Emerging viruses
- Picornavirus
- Virus discovery
ASJC Scopus subject areas
- Virology