Abstract
Hexavalent chromium [Cr (VI)] contributes a significant health risk and causes a number of chronic diseases and cancers. While the genotoxic and carcinogenic effects of hexavalent chromium exposure are explicit and better-characterized, the exact mechanism underlying the carcinogenic process of Cr (VI) is still a matter of debate. In recent years, studies have shown that epigenetic modifications, especially DNA methylation, may play a significant role in Cr (VI)-induced carcinogenesis. The aim of this review is to summarize our understanding regarding the effects of Cr (VI) on global and gene-specific DNA methylation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 133-145 |
| Number of pages | 13 |
| Journal | Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews |
| Volume | 37 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 3 2019 |
| Externally published | Yes |
Keywords
- DNA methylation
- hexavalent chromium
- hypermethylation
- hypomethylation
ASJC Scopus subject areas
- Health, Toxicology and Mutagenesis
- Cancer Research
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