@inbook{5d17d6eaa4a641a68a506032377e4248,
title = "Drug addiction and histone code alterations",
abstract = "Acute and prolonged exposure to drugs of abuse induces changes in gene expression, synaptic function, and neural plasticity in brain regions involved in reward. Numerous genes are involved in this process, and persistent changes in gene expression coincide with epigenetic histone modifications and DNA methylation. Histone modifications are attractive regulatory mechanisms, which can encode complex environmental signals in the genome of postmitotic cells, like neurons. Recently, it has been demonstrated that specific histone modifications are involved in addiction-related gene regulatory mechanisms, by a diverse set of histone-modifying enzymes and readers. These histone modifiers and readers may prove to be valuable pharmacological targets for effective treatments for drug addiction.",
keywords = "Addiction, Drug of abuse, Epigenetics, Histone modification, Reward circuitry",
author = "Kim, {Hee Dae} and Tanessa Call and Samantha Magazu and Deveroux Ferguson",
note = "Funding Information: This work was supported by grants from NARSAD and NIMH. Publisher Copyright: {\textcopyright} 2017, Springer International Publishing AG.",
year = "2017",
doi = "10.1007/978-3-319-53889-1_7",
language = "English (US)",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer New York LLC",
pages = "127--143",
booktitle = "Advances in Experimental Medicine and Biology",
}