Early events in coccidioidomycosis

Fariba M. Donovan, Daniel Powell, Marc Orbach, Jeffrey Frelinger, John N. Galgiani

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Since its description nearly 130 years ago, hundreds of studies have deepened our understanding of coccidioidomycosis, also known as valley fever (VF), and provided useful diagnostic tests and treatments for the disease caused by the dimorphic fungi Coccidioides spp. In general, most of the literature has addressed well-established infections and has described patients who have experienced major complications. In contrast, little attention has been given to the earliest consequences of the pathogen-host interaction and its implications for disease manifestation, progression, and resolution. The purpose of this review is to highlight published studies on early coccidioidomycosis, identify gaps in our knowledge, and suggest new or former research areas that might be or remain fertile ground for insight into the early stages of this invasive fungal disease.

Original languageEnglish (US)
Article numbere00112-19
JournalClinical Microbiology Reviews
Issue number1
StatePublished - Jan 2020


  • Coccidioides research
  • Coccidioidomycosis
  • Early coccidioidomycosis
  • Early events in valley fever

ASJC Scopus subject areas

  • General Medicine


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