Abstract
A novel organocatalytic, enantioselective domino double Michael addition reaction of α,β-unsaturated aldehydes with ethyl 4-mercapto-2- butenoate has been developed. The process is promoted by chiral diphenylprolinol TMS ether to give chiral tetrahydrothiophenes in high to excellent levels of enantioselectivities.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1833-1835 |
| Number of pages | 3 |
| Journal | Organic Letters |
| Volume | 9 |
| Issue number | 9 |
| DOIs | |
| State | Published - Apr 26 2007 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry