Enflurane biotransformation in humans

M. S. Miller; A. J. Gandolfi

doi:10.1016/0024-3205(80)90370-7

Enflurane biotransformation in humans

M. S. Miller, A. J. Gandolfi

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The biotransformation of enflurane was investigated in humans. Liquid anion exchange chromatography of extracts of urine obtained during and following enflurane anesthesia revealed the presence of two organic fluoride containing enflurane metabolites. Gas chromatographic-mass spectroscopic analysis of lyophilized urine extracts indicated the presence of 2-difluoromethoxy- 2,2-difluoro-acetic acid. These results suggest that enflurane undergoes both oxidative dechlorination at the β carbon and O-demethylation at the ether linkage in humans.

Original language	English (US)
Pages (from-to)	1465-1468
Number of pages	4
Journal	Life Sciences
Volume	27
Issue number	16
DOIs	https://doi.org/10.1016/0024-3205(80)90370-7
State	Published - 1980

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

Access to Document

10.1016/0024-3205(80)90370-7

Cite this

@article{35f8e37be7f44b8c9f9029a8d24fa965,

title = "Enflurane biotransformation in humans",

abstract = "The biotransformation of enflurane was investigated in humans. Liquid anion exchange chromatography of extracts of urine obtained during and following enflurane anesthesia revealed the presence of two organic fluoride containing enflurane metabolites. Gas chromatographic-mass spectroscopic analysis of lyophilized urine extracts indicated the presence of 2-difluoromethoxy- 2,2-difluoro-acetic acid. These results suggest that enflurane undergoes both oxidative dechlorination at the β carbon and O-demethylation at the ether linkage in humans.",

author = "Miller, {M. S.} and Gandolfi, {A. J.}",

year = "1980",

doi = "10.1016/0024-3205(80)90370-7",

language = "English (US)",

volume = "27",

pages = "1465--1468",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "16",

}

TY - JOUR

T1 - Enflurane biotransformation in humans

AU - Miller, M. S.

AU - Gandolfi, A. J.

PY - 1980

Y1 - 1980

N2 - The biotransformation of enflurane was investigated in humans. Liquid anion exchange chromatography of extracts of urine obtained during and following enflurane anesthesia revealed the presence of two organic fluoride containing enflurane metabolites. Gas chromatographic-mass spectroscopic analysis of lyophilized urine extracts indicated the presence of 2-difluoromethoxy- 2,2-difluoro-acetic acid. These results suggest that enflurane undergoes both oxidative dechlorination at the β carbon and O-demethylation at the ether linkage in humans.

AB - The biotransformation of enflurane was investigated in humans. Liquid anion exchange chromatography of extracts of urine obtained during and following enflurane anesthesia revealed the presence of two organic fluoride containing enflurane metabolites. Gas chromatographic-mass spectroscopic analysis of lyophilized urine extracts indicated the presence of 2-difluoromethoxy- 2,2-difluoro-acetic acid. These results suggest that enflurane undergoes both oxidative dechlorination at the β carbon and O-demethylation at the ether linkage in humans.

UR - http://www.scopus.com/inward/record.url?scp=0019171135&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019171135&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(80)90370-7

DO - 10.1016/0024-3205(80)90370-7

M3 - Article

C2 - 7442453

SN - 0024-3205

VL - 27

SP - 1465

EP - 1468

JO - Life Sciences

JF - Life Sciences

IS - 16

ER -

Enflurane biotransformation in humans

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this