Abstract
Spaceflight uniquely alters the physiology of both human cells and microbial pathogens, stimulating cellular and molecular changes directly relevant to infectious disease. However, the influence of this environment on host–pathogen interactions remains poorly understood. Here we report our results from the STL-IMMUNE study flown aboard Space Shuttle mission STS-131, which investigated multi-omic responses (transcriptomic, proteomic) of human intestinal epithelial cells to infection with Salmonella Typhimurium when both host and pathogen were simultaneously exposed to spaceflight. To our knowledge, this was the first in-flight infection and dual RNA-seq analysis using human cells.
Original language | English (US) |
---|---|
Article number | 9 |
Journal | npj Microgravity |
Volume | 7 |
Issue number | 1 |
DOIs | |
State | Published - Dec 2021 |
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Materials Science (miscellaneous)
- Biochemistry, Genetics and Molecular Biology (miscellaneous)
- Agricultural and Biological Sciences (miscellaneous)
- Physics and Astronomy (miscellaneous)
- Space and Planetary Science
Fingerprint
Dive into the research topics of 'Evaluating the effect of spaceflight on the host–pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium'. Together they form a unique fingerprint.Press/Media
-
First Infection of Human Cells During Spaceflight Analyzed by Researchers
Nickerson, C., Barrila, J. & Halden, R.
4/5/21
2 items of Media coverage
Press/Media: Press / Media