@inproceedings{34640350bafb4ad0acbe7b8a4c7b4791,
title = "Evaluation of Down-scatter Contamination in Multi-Pinhole 123I-IMP Brain Perfusion SPECT Imaging",
abstract = "Brain imaging with 123I radionuclide remains essential to assess the dopamine transporter activity or cerebral blood flow in various cerebral disorders. However, imaging with 123I-labeled tracers suffers from down-scatter contaminations from the emission of a series of high-energy (>183 keV, ~3% abundance) gamma photons in addition to the primary photons (159 keV, 83% abundance). In this work, we investigated through simulation studies the effect of down-scatter contamination on image quality using multiple pinhole configurations and aperture sizes of AdaptiSPECT-C, which is a next-generation multi-pinhole system currently under construction. We simulated a brain phantom with source distribution for the perfusion imaging agent 123I-IMP as imaged 1h post injection. To enable comparison of imaging without down-scatter interactions, reconstructions were compared qualitatively and quantitively to the ones obtained from acquisition of similar activity distribution simulated for solely the 159-keV principal emission of 123I. In this initial study, we demonstrated through quantification and visual inspection of cerebral perfusion reconstruction incorporating down-scatter correction that the inclusion of down-scatter counts does not hamper the imaging performance of AdaptiSPECT-C even for the pinhole combination the most contaminated by such interactions. We have initiated a comparison of these findings against the ones obtained from a dual-head system employing parallel-hole collimator for which acquisition is considerably more impacted by down-scatter interactions.",
keywords = "AdaptiSPECT-C, GATE Monte-Carlo simulation, I-IMP SPECT imaging, cerebral blood-flow perfusion, down-scatter contaminations",
author = "Benjamin Auer and {De Beenhouwer}, Jan and Kalluri, {Kesava S.} and Clifford Lindsay and Richards, {R. Garrett} and Micaehla May and Kupinski, {Matthew A.} and Kuo, {Phillip H.} and Furenlid, {Lars R.} and King, {Michael A.}",
note = "Publisher Copyright: {\textcopyright} 2021 IEEE.; 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2021 ; Conference date: 01-01-2021",
year = "2021",
doi = "10.1109/NSS/MIC44867.2021.9875469",
language = "English (US)",
series = "2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
editor = "Hideki Tomita and Tatsuya Nakamura",
booktitle = "2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022",
}