@article{aad9ce8a2ad146e58e1ca24dfbd6ff55,
title = "Exercise for Depression: A Feasibility Trial Exploring Neural Mechanisms",
abstract = " Objective: The aim of this study was to test the feasibility of an exercise augmentation to pharmacotherapy in depressed younger and older adults while exploring neural mechanisms. Methods: A randomized, double-blind, controlled clinical trial was conducted in 15 inactive younger (20–39 years)and older (60–79 years)adults meeting Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, criteria for a major depressive episode (https://clinicaltrials.gov/ct2/show/NCT02407704). Participants were randomized to receive a 12-week regimen of venlafaxine XR or venlafaxine XR plus supervised exercise. Cardiorespiratory fitness was assessed using a submaximal VO 2 test, and neuroimaging assessments were conducted using a Siemans MAGNETOM 7-Tesla magnetic resonance scanner at the University of Pittsburgh. Results: Attrition was 38% and 14% for the medication and exercise groups, respectively. Attendance was 91% for the exercise intervention. Exploratory analyses revealed an association between improvement in fitness and increased cortical thickness in the anterior cingulate cortex. Conclusion: Exercise augmentation to pharmacotherapy is feasible for depressed younger and older adults and may have neural benefits in a core brain region implicated in depression.",
keywords = "Exercise, MRI, brain, depression",
author = "Swathi Gujral and Howard Aizenstein and Reynolds, {Charles F.} and Butters, {Meryl A.} and George Grove and Karp, {Jordan F.} and Erickson, {Kirk I.}",
note = "Funding Information: Swathi Gujral, Ph.D., was supported by the United States National Science Foundation Graduate Research Fellowship Program grant 2014192810 and is currently funded through the VA Mental Illness Research, Education, and Clinical Center Advanced Fellowship. Kirk I. Erickson, Ph.D., was supported by research grants R01 DK095172, P30 AG024827, P30 MH90333, R01 CA221882, R01 AG053952, and R01 CA196762. Partial support was also received from the University of Pittsburgh Medical Center Endowment in Geriatric Psychiatry (Charles F. Reynolds III, M.D., and Howard Aizenstein, M.D., Ph.D.). Meryl A. Butters, Ph.D., was supported by research grants P50 AG005133 and P30 MH090333. Jordan F. Karp, M.D., was supported by research grant P30 MH090333; he has also received medication supplies from Indivior and Pfizer for investigator-initiated trials. Financial support for the development of this article was supplied exclusively by the Advanced Center in Intervention and Services Research in Late-Life Depression Prevention (P30MH090333). Funding Information: Swathi Gujral, Ph.D., was supported by the United States National Science Foundation Graduate Research Fellowship Program grant 2014192810 and is currently funded through the VA Mental Illness Research, Education, and Clinical Center Advanced Fellowship. Kirk I. Erickson, Ph.D., was supported by research grants R01 DK095172, P30 AG024827, P30 MH90333, R01 CA221882, R01 AG053952, and R01 CA196762. Partial support was also received from the University of Pittsburgh Medical Center Endowment in Geriatric Psychiatry (Charles F. Reynolds III, M.D., and Howard Aizenstein, M.D., Ph.D.). Meryl A. Butters, Ph.D., was supported by research grants P50 AG005133 and P30 MH090333. Jordan F. Karp, M.D., was supported by research grant P30 MH090333; he has also received medication supplies from Indivior and Pfizer for investigator-initiated trials. Financial support for the development of this article was supplied exclusively by the Advanced Center in Intervention and Services Research in Late-Life Depression Prevention (P30MH090333). Funding Information: Swathi Gujral, Ph.D. was supported by the United States National Science Foundation Graduate Research Fellowship Program grant 2014192810 and is currently funded through the VA Mental Illness Research, Education, and Clinical Center Advanced Fellowship. Kirk I. Erickson, Ph.D. was supported by research grants R01 DK095172, P30 AG024827, P30 MH90333, R01 CA221882, R01 AG053952, and R01 CA196762. Partial support was also received from the University of Pittsburgh Medical Center Endowment in Geriatric Psychiatry (Charles F. Reynolds III, M.D. and Howard Aizenstein, M.D. Ph.D.). Meryl A. Butters, Ph.D. was supported by research grants P50 AG005133 and P30 MH090333. Jordan F. Karp, M.D. was supported by research grant P30 MH090333; he has also received medication supplies from Indivior and Pfizer for investigator-initiated trials. Financial support for the development of this article was supplied exclusively by the Advanced Center in Intervention and Services Research in Late-Life Depression Prevention (P30MH090333). Swathi Gujral, Ph.D. Howard Aizenstein, M.D. Ph.D. Charles F. Reynolds III, M.D. Meryl A. Butters, Ph.D. and Kirk I. Erickson, Ph.D. were involved in study concept and design. Swathi Gujral, Ph.D. George Grove, M.S. Meryl A. Butters, Ph.D. Howard Aizenstein, M.D. Ph.D. and Kirk I. Erickson, Ph.D. were involved in analysis and interpretation of data. All authors (Swathi Gujral, Ph.D. Howard Aizenstein, M.D. Ph.D. Charles F. Reynolds III, M.D. Meryl A. Butters, Ph.D. Jordan F. Karp, M.D. George Grove, M.S. Kirk I. Erickson, Ph.D.)were involved in acquisition of subjects and data and preparation of the manuscript. Publisher Copyright: {\textcopyright} 2019",
year = "2019",
month = jun,
doi = "10.1016/j.jagp.2019.01.012",
language = "English (US)",
volume = "27",
pages = "611--616",
journal = "American Journal of Geriatric Psychiatry",
issn = "1064-7481",
publisher = "Lippincott Williams and Wilkins",
number = "6",
}