TY - JOUR
T1 - How preclinical models of menopause can inform clinical care
T2 - A focus on midlife and reciprocal communication between clinical and preclinical science
AU - Bimonte-Nelson, Heather A.
AU - Bernaud, Victoria E.
N1 - Funding Information: Support was provided to HBN by the National Institute on Aging ( AG028084 ), state of Arizona, Arizona Department of Health Services ( ADHS 14-052688 ), and the NIH Arizona Alzheimer's Disease Core Center ( P30AG019610 ); VEB received support in part from a Sharon Manne award from the Psychology Department at Arizona State University. Publisher Copyright: © 2023
PY - 2023/2
Y1 - 2023/2
N2 - Midlife in women typically includes the menopausal transition, a time of hormonal transformation, adaptation, and reorganization. Coincident with this dynamic period of physiological change, there are putatively modifiable factors that influence disease, short-term and long-term health outcomes, symptom emergence, and longevity. The menopause transition could be considered a window of vulnerability; however, it is also a window of opportunity for intervention. Thus, the menopause transition is a critical sensitive window whereby there is opportunity for turning points for healthy aging trajectories. Preclinical research can aid in this pursuit of scientific discovery for modifiable factors and treatments, and their particular parameters. Rodent menopause models include surgical and transitional variations, allowing detection of precise determinants impacting menopause-related outcomes. These models permit systematic manipulation of endogenous and exogenous hormone exposures across the lifespan, with infinite outcome measurements ranging from molecular to behavioral. This research is uniquely poised to address complex, interactive hypotheses with extensive control in a relatively short timeframe, including dissociation of age and menopause effects. To understand the many dynamic changes with menopause, iterative and reciprocal communication between clinical and preclinical domains of science is key.
AB - Midlife in women typically includes the menopausal transition, a time of hormonal transformation, adaptation, and reorganization. Coincident with this dynamic period of physiological change, there are putatively modifiable factors that influence disease, short-term and long-term health outcomes, symptom emergence, and longevity. The menopause transition could be considered a window of vulnerability; however, it is also a window of opportunity for intervention. Thus, the menopause transition is a critical sensitive window whereby there is opportunity for turning points for healthy aging trajectories. Preclinical research can aid in this pursuit of scientific discovery for modifiable factors and treatments, and their particular parameters. Rodent menopause models include surgical and transitional variations, allowing detection of precise determinants impacting menopause-related outcomes. These models permit systematic manipulation of endogenous and exogenous hormone exposures across the lifespan, with infinite outcome measurements ranging from molecular to behavioral. This research is uniquely poised to address complex, interactive hypotheses with extensive control in a relatively short timeframe, including dissociation of age and menopause effects. To understand the many dynamic changes with menopause, iterative and reciprocal communication between clinical and preclinical domains of science is key.
KW - Aging
KW - Hormone
KW - Menopause
KW - Midlife
KW - Model
KW - Preclinical
KW - Rat
UR - http://www.scopus.com/inward/record.url?scp=85150463951&partnerID=8YFLogxK
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U2 - 10.1016/j.coemr.2023.100434
DO - 10.1016/j.coemr.2023.100434
M3 - Review article
SN - 2451-9650
VL - 28
JO - Current Opinion in Endocrine and Metabolic Research
JF - Current Opinion in Endocrine and Metabolic Research
M1 - 100434
ER -