Identification of a novel human rhinovirus C type by antibody capture VIDISCA-454

Seyed Mohammad Jazaeri Farsani; Bas B.Oude Munnink; Marta Canuti; Martin Deijs; Matthew Cotten; Maarten F. Jebbink; Joost Verhoeven; Paul Kellam; Katherine Loens; Herman Goossens; Margareta Ieven; Lia van der Hoek

doi:10.3390/v7010239

Identification of a novel human rhinovirus C type by antibody capture VIDISCA-454

Seyed Mohammad Jazaeri Farsani
, Bas B.Oude Munnink
, Marta Canuti
, Martin Deijs
, Matthew Cotten
, Maarten F. Jebbink
, Joost Verhoeven
, Paul Kellam
, Katherine Loens
, Herman Goossens
, Margareta Ieven
, Lia van der Hoek

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Causative agents for more than 30 percent of respiratory infections remain unidentified, suggesting that unknown respiratory pathogens might be involved. In this study, antibody capture VIDISCA-454 (virus discovery cDNA-AFLP combined with Roche 454 high-throughput sequencing) resulted in the discovery of a novel type of rhinovirus C (RV-C). The virus has an RNA genome of at least 7054 nt and carries the characteristics of rhinovirus C species. The gene encoding viral protein 1, which is used for typing, has only 81% nucleotide sequence identity with the closest known RV-C type, and, therefore, the virus represents the first member of a novel type, named RV-C54.

Original language	English (US)
Pages (from-to)	239-251
Number of pages	13
Journal	Viruses
Volume	7
Issue number	1
DOIs	https://doi.org/10.3390/v7010239
State	Published - Jan 19 2015
Externally published	Yes

Keywords

Antibody capture VIDISCA-454
Rhinovirus C54
Virus discovery

ASJC Scopus subject areas

Infectious Diseases
Virology

Access to Document

10.3390/v7010239

Cite this

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title = "Identification of a novel human rhinovirus C type by antibody capture VIDISCA-454",

abstract = "Causative agents for more than 30 percent of respiratory infections remain unidentified, suggesting that unknown respiratory pathogens might be involved. In this study, antibody capture VIDISCA-454 (virus discovery cDNA-AFLP combined with Roche 454 high-throughput sequencing) resulted in the discovery of a novel type of rhinovirus C (RV-C). The virus has an RNA genome of at least 7054 nt and carries the characteristics of rhinovirus C species. The gene encoding viral protein 1, which is used for typing, has only 81\% nucleotide sequence identity with the closest known RV-C type, and, therefore, the virus represents the first member of a novel type, named RV-C54.",

keywords = "Antibody capture VIDISCA-454, Rhinovirus C54, Virus discovery",

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note = "Publisher Copyright: {\textcopyright} 2015 by the authors; licensee MDPI, Basel, Switzerland.",

year = "2015",

month = jan,

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doi = "10.3390/v7010239",

language = "English (US)",

volume = "7",

pages = "239--251",

journal = "Viruses",

issn = "1999-4915",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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AU - Farsani, Seyed Mohammad Jazaeri

AU - Munnink, Bas B.Oude

AU - Canuti, Marta

AU - Deijs, Martin

AU - Cotten, Matthew

AU - Jebbink, Maarten F.

AU - Verhoeven, Joost

AU - Kellam, Paul

AU - Loens, Katherine

AU - Goossens, Herman

AU - Ieven, Margareta

AU - van der Hoek, Lia

PY - 2015/1/19

Y1 - 2015/1/19

N2 - Causative agents for more than 30 percent of respiratory infections remain unidentified, suggesting that unknown respiratory pathogens might be involved. In this study, antibody capture VIDISCA-454 (virus discovery cDNA-AFLP combined with Roche 454 high-throughput sequencing) resulted in the discovery of a novel type of rhinovirus C (RV-C). The virus has an RNA genome of at least 7054 nt and carries the characteristics of rhinovirus C species. The gene encoding viral protein 1, which is used for typing, has only 81% nucleotide sequence identity with the closest known RV-C type, and, therefore, the virus represents the first member of a novel type, named RV-C54.

AB - Causative agents for more than 30 percent of respiratory infections remain unidentified, suggesting that unknown respiratory pathogens might be involved. In this study, antibody capture VIDISCA-454 (virus discovery cDNA-AFLP combined with Roche 454 high-throughput sequencing) resulted in the discovery of a novel type of rhinovirus C (RV-C). The virus has an RNA genome of at least 7054 nt and carries the characteristics of rhinovirus C species. The gene encoding viral protein 1, which is used for typing, has only 81% nucleotide sequence identity with the closest known RV-C type, and, therefore, the virus represents the first member of a novel type, named RV-C54.

KW - Antibody capture VIDISCA-454

KW - Rhinovirus C54

KW - Virus discovery

UR - https://www.scopus.com/pages/publications/84921696506

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Identification of a novel human rhinovirus C type by antibody capture VIDISCA-454

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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