Immobilized amines as mimetic heparin-binding domains for cell surface proteoglycan-mediated cell adhesion

Stephen Massia; J. A. Hubbell

Immobilized amines as mimetic heparin-binding domains for cell surface proteoglycan-mediated cell adhesion

Stephen Massia, J. A. Hubbell

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

In this study, we investigate the nature of human foreskin fibroblast (HFF) adhesion in the absence of serum proteins to glass substrates containing covalently linked amines. Based on this study, it can be concluded that cell adhesion to diamine derivatized substrates, which are positively charged at neutral pH, is chondroitin sulfate proteoglycan-mediated in the HFF. The immobilized N, N-dimethyl ED provided a good functional mimic of the so-called heparin-binding domain of cell adhesion proteins for this cell type.

Original language	English (US)
Title of host publication	Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium
Place of Publication	Algonquin, IL, United States
Publisher	Publ by Soc for Biomaterials
Pages	240
Number of pages	1
Volume	14
State	Published - 1991
Externally published	Yes
Event	17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium - Scottsdale, AZ, USA Duration: May 1 1991 → May 5 1991

Other

Other	17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium
City	Scottsdale, AZ, USA
Period	5/1/91 → 5/5/91

ASJC Scopus subject areas

General Materials Science

Cite this

Immobilized amines as mimetic heparin-binding domains for cell surface proteoglycan-mediated cell adhesion. / Massia, Stephen; Hubbell, J. A.
Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. Vol. 14 Algonquin, IL, United States: Publ by Soc for Biomaterials, 1991. p. 240.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Massia, S & Hubbell, JA 1991, Immobilized amines as mimetic heparin-binding domains for cell surface proteoglycan-mediated cell adhesion. in Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium. vol. 14, Publ by Soc for Biomaterials, Algonquin, IL, United States, pp. 240, 17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium, Scottsdale, AZ, USA, 5/1/91.

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BT - Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium

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CY - Algonquin, IL, United States

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Y2 - 1 May 1991 through 5 May 1991

ER -

Immobilized amines as mimetic heparin-binding domains for cell surface proteoglycan-mediated cell adhesion

Abstract

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ASJC Scopus subject areas

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