TY - JOUR
T1 - Immune responses in the skin in old age
AU - Vukmanovic-Stejic, Milica
AU - Rustin, Malcolm H.A.
AU - Nikolich-Zugich, Janko
AU - Akbar, Arne N.
N1 - Funding Information: Authors would like to acknowledge support of the MRC UK (grant award G0901102 to MV-S), BBSRC, British Skin Foundation and Dermatrust (to AA) and National Institutes of Health (grant awards AG20719 and AG03319 , National Institute on Ageing to JN-Ž).
PY - 2011/8
Y1 - 2011/8
N2 - A marked increase in the susceptibility to cutaneous infections and malignancies has been observed in older humans indicating that cutaneous immunity becomes defective with age. In this review we will focus on recent developments in the understanding of age-related changes in immune function of the skin with a particular emphasis on how alterations in the interaction between cells involved in innate and adaptive immunity leads to decreased cutaneous antigen-specific T cell immunosurveillance.
AB - A marked increase in the susceptibility to cutaneous infections and malignancies has been observed in older humans indicating that cutaneous immunity becomes defective with age. In this review we will focus on recent developments in the understanding of age-related changes in immune function of the skin with a particular emphasis on how alterations in the interaction between cells involved in innate and adaptive immunity leads to decreased cutaneous antigen-specific T cell immunosurveillance.
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U2 - 10.1016/j.coi.2011.05.008
DO - 10.1016/j.coi.2011.05.008
M3 - Review article
C2 - 21703840
SN - 0952-7915
VL - 23
SP - 525
EP - 531
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 4
ER -