TY - JOUR
T1 - Immunity to acute virus infections with advanced age
AU - Nikolich-Žugich, Janko
AU - Bradshaw, Christine M.
AU - Uhrlaub, Jennifer L.
AU - Watanabe, Makiko
N1 - Funding Information: Partially supported by USPHS Awards AG020719, AG057701, AG052359 and AG060900, and the Bowman Professorship in Medical Sciences, to J. N-Ž. Sponsors had no influence on design, performance, analysis or any other aspects of manuscript preparation or on its publication.Dr Nikolich is Chair of the Scientific Advisory Board of, and receives funding for a research project from, the Young Blood Institute, Inc., (YBI), a non-profit organization seeking to evaluate benefits of plasma exchange therapies for healthy aging and diseases of aging. Neither the YBI, nor any of government supporters of his research or of other authors, had any influence in design, execution or discussion of any results presented herein. Publisher Copyright: © 2020 Elsevier B.V.
PY - 2021/2
Y1 - 2021/2
N2 - New infections in general, and new viral infections amongst them, represent a serious challenge to an older organism. This review discusses the age-related alterations in responsiveness to infection from the standpoint of virus:host relationship and the host physiological whole-organism and specific immune response to the virus. Changes with age in the innate and adaptive immune system homeostasis and function are reviewed briefly. This is followed by a review of specific alterations and defects in the response of older organisms (chiefly mice and humans) to acute (particularly emerging and re-emerging) viral infections, with a very brief summary of the response to latent persistent infections. Finally, we provide a brief summary of the perspectives for possible interventions to enhance antiviral immunity.
AB - New infections in general, and new viral infections amongst them, represent a serious challenge to an older organism. This review discusses the age-related alterations in responsiveness to infection from the standpoint of virus:host relationship and the host physiological whole-organism and specific immune response to the virus. Changes with age in the innate and adaptive immune system homeostasis and function are reviewed briefly. This is followed by a review of specific alterations and defects in the response of older organisms (chiefly mice and humans) to acute (particularly emerging and re-emerging) viral infections, with a very brief summary of the response to latent persistent infections. Finally, we provide a brief summary of the perspectives for possible interventions to enhance antiviral immunity.
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U2 - 10.1016/j.coviro.2020.09.007
DO - 10.1016/j.coviro.2020.09.007
M3 - Review article
C2 - 33160186
SN - 1879-6257
VL - 46
SP - 45
EP - 58
JO - Current opinion in virology
JF - Current opinion in virology
ER -