Impact of thrombolytic therapy on left ventricular mural thrombi in acute myocardial infarction

A. Christian Held; Joel M. Gore; John Paraskos; Linda A. Rape; Steven P. Ball; Jeanne M. Corrao; Joseph S. Alpert

doi:10.1016/0002-9149(88)90231-7

Impact of thrombolytic therapy on left ventricular mural thrombi in acute myocardial infarction

A. Christian Held, Joel M. Gore, John Paraskos, Linda A. Rape, Steven P. Ball, Jeanne M. Corrao, Joseph S. Alpert

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Abstract

Left ventricular (LV) mural thrombi have long been recognized as a complication of acute myocardial infarction (AMI). Recent echocardiographic studies suggest an incidence of 2 to 18% in patients with AMI. Anterior infarctions are found to have a much higher incidence of mural thrombus than inferior infarctions.¹ Previous reports have noted conflicting results regarding the effect of thrombolysis on the formation of LV mural thrombi after AMI.^2-4 The aim of this study was 2-fold: to examine if systemic thrombolytic therapy using either tissue plasminogen activator or streptokinase reduces the incidence of LV mural thrombi early after AM1 compared with conventional treatment, and to determine if reperfusion of the infarct-related artery was associated with a lower incidence of LV mural thrombi.

Original language	English (US)
Pages (from-to)	310-311
Number of pages	2
Journal	The American journal of cardiology
Volume	62
Issue number	4
DOIs	https://doi.org/10.1016/0002-9149(88)90231-7
State	Published - Aug 1 1988

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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title = "Impact of thrombolytic therapy on left ventricular mural thrombi in acute myocardial infarction",

abstract = "Left ventricular (LV) mural thrombi have long been recognized as a complication of acute myocardial infarction (AMI). Recent echocardiographic studies suggest an incidence of 2 to 18% in patients with AMI. Anterior infarctions are found to have a much higher incidence of mural thrombus than inferior infarctions.1 Previous reports have noted conflicting results regarding the effect of thrombolysis on the formation of LV mural thrombi after AMI.2-4 The aim of this study was 2-fold: to examine if systemic thrombolytic therapy using either tissue plasminogen activator or streptokinase reduces the incidence of LV mural thrombi early after AM1 compared with conventional treatment, and to determine if reperfusion of the infarct-related artery was associated with a lower incidence of LV mural thrombi.",

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AU - Held, A. Christian

AU - Gore, Joel M.

AU - Paraskos, John

AU - Rape, Linda A.

AU - Ball, Steven P.

AU - Corrao, Jeanne M.

AU - Alpert, Joseph S.

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N2 - Left ventricular (LV) mural thrombi have long been recognized as a complication of acute myocardial infarction (AMI). Recent echocardiographic studies suggest an incidence of 2 to 18% in patients with AMI. Anterior infarctions are found to have a much higher incidence of mural thrombus than inferior infarctions.1 Previous reports have noted conflicting results regarding the effect of thrombolysis on the formation of LV mural thrombi after AMI.2-4 The aim of this study was 2-fold: to examine if systemic thrombolytic therapy using either tissue plasminogen activator or streptokinase reduces the incidence of LV mural thrombi early after AM1 compared with conventional treatment, and to determine if reperfusion of the infarct-related artery was associated with a lower incidence of LV mural thrombi.

AB - Left ventricular (LV) mural thrombi have long been recognized as a complication of acute myocardial infarction (AMI). Recent echocardiographic studies suggest an incidence of 2 to 18% in patients with AMI. Anterior infarctions are found to have a much higher incidence of mural thrombus than inferior infarctions.1 Previous reports have noted conflicting results regarding the effect of thrombolysis on the formation of LV mural thrombi after AMI.2-4 The aim of this study was 2-fold: to examine if systemic thrombolytic therapy using either tissue plasminogen activator or streptokinase reduces the incidence of LV mural thrombi early after AM1 compared with conventional treatment, and to determine if reperfusion of the infarct-related artery was associated with a lower incidence of LV mural thrombi.

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Impact of thrombolytic therapy on left ventricular mural thrombi in acute myocardial infarction

Abstract

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