Improved synthesis of d,l-fluorocitric acid

Ruben Vardanyan; Vlad K. Kumirov; Victor J. Hruby

doi:10.1016/j.jfluchem.2011.07.006

Improved synthesis of d,l-fluorocitric acid

Ruben Vardanyan
, Vlad K. Kumirov
, Victor J. Hruby

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We propose a decagram synthesis of commercially unavailable fluorocitric acid. The synthesis begins with benzyl fluoroacetate, which is converted to dibenzyl 2-fluoro-3-oxosuccinate, followed by condensation with malonic acid or its monobenzyl ester and subsequent hydrogenolysis.

Original language	English (US)
Pages (from-to)	920-924
Number of pages	5
Journal	Journal of Fluorine Chemistry
Volume	132
Issue number	11
DOIs	https://doi.org/10.1016/j.jfluchem.2011.07.006
State	Published - Nov 2011
Externally published	Yes

Keywords

Fluorocitric acid

ASJC Scopus subject areas

Environmental Chemistry
Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.1016/j.jfluchem.2011.07.006

Cite this

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title = "Improved synthesis of d,l-fluorocitric acid",

abstract = "We propose a decagram synthesis of commercially unavailable fluorocitric acid. The synthesis begins with benzyl fluoroacetate, which is converted to dibenzyl 2-fluoro-3-oxosuccinate, followed by condensation with malonic acid or its monobenzyl ester and subsequent hydrogenolysis.",

keywords = "Fluorocitric acid",

author = "Ruben Vardanyan and Kumirov, \{Vlad K.\} and Hruby, \{Victor J.\}",

note = "Funding Information: This work was supported by grants from the U.S. Public Health Service , National Institute of Health , DA 13449 and DA 06284 .",

year = "2011",

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language = "English (US)",

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journal = "Journal of Fluorine Chemistry",

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AU - Vardanyan, Ruben

AU - Kumirov, Vlad K.

AU - Hruby, Victor J.

N1 - Funding Information: This work was supported by grants from the U.S. Public Health Service , National Institute of Health , DA 13449 and DA 06284 .

PY - 2011/11

Y1 - 2011/11

N2 - We propose a decagram synthesis of commercially unavailable fluorocitric acid. The synthesis begins with benzyl fluoroacetate, which is converted to dibenzyl 2-fluoro-3-oxosuccinate, followed by condensation with malonic acid or its monobenzyl ester and subsequent hydrogenolysis.

AB - We propose a decagram synthesis of commercially unavailable fluorocitric acid. The synthesis begins with benzyl fluoroacetate, which is converted to dibenzyl 2-fluoro-3-oxosuccinate, followed by condensation with malonic acid or its monobenzyl ester and subsequent hydrogenolysis.

KW - Fluorocitric acid

UR - https://www.scopus.com/pages/publications/80052734102

UR - https://www.scopus.com/pages/publications/80052734102#tab=citedBy

U2 - 10.1016/j.jfluchem.2011.07.006

DO - 10.1016/j.jfluchem.2011.07.006

M3 - Article

SN - 0022-1139

VL - 132

SP - 920

EP - 924

JO - Journal of Fluorine Chemistry

JF - Journal of Fluorine Chemistry

IS - 11

ER -

Improved synthesis of d,l-fluorocitric acid

Abstract

Keywords

ASJC Scopus subject areas

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