Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives

Thomas Boyer; Céline Blaye; Nicolas Larmonier; Charlotte Domblides

doi:10.3390/cells11030554

Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives

Thomas Boyer, Céline Blaye, Nicolas Larmonier, Charlotte Domblides

Children's Research, Center of

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Tumor metabolism plays a crucial role in sustaining tumorigenesis. There have been increasing reports regarding the role of tumor metabolism in the control of immune cell functions, generating a potent immunosuppressive contexture that can lead to immune escape. The metabolic reprogramming of tumor cells and the immune escape are two major hallmarks of cancer, with several instances of crosstalk between them. In this paper, we review the effects of tumor metabolism on immune cells, focusing on myeloid cells due to their important role in tumorigenesis and immunosuppression from the early stages of the disease. We also discuss ways to target this specific crosstalk in cancer patients.

Original language	English (US)
Article number	554
Journal	Cells
Volume	11
Issue number	3
DOIs	https://doi.org/10.3390/cells11030554
State	Published - Feb 1 2022

Keywords

Cancer
Immunomodulation
Immunotherapy
Macrophages
Metabolism
Myeloid cells
Myeloid-derived suppressive cells
Therapeutic strategies

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.3390/cells11030554

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title = "Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives",

abstract = "Tumor metabolism plays a crucial role in sustaining tumorigenesis. There have been increasing reports regarding the role of tumor metabolism in the control of immune cell functions, generating a potent immunosuppressive contexture that can lead to immune escape. The metabolic reprogramming of tumor cells and the immune escape are two major hallmarks of cancer, with several instances of crosstalk between them. In this paper, we review the effects of tumor metabolism on immune cells, focusing on myeloid cells due to their important role in tumorigenesis and immunosuppression from the early stages of the disease. We also discuss ways to target this specific crosstalk in cancer patients.",

keywords = "Cancer, Immunomodulation, Immunotherapy, Macrophages, Metabolism, Myeloid cells, Myeloid-derived suppressive cells, Therapeutic strategies",

author = "Thomas Boyer and C{\'e}line Blaye and Nicolas Larmonier and Charlotte Domblides",

note = "Funding Information: Funding: This research was funded by Ligue Nationale contre le Cancer (N.L.), the SIRIC-BRIO (N.L.), Fundation ARC (C.B.), Canc{\'e}rop{\^o}le Grand Sud-Ouest (C.D.) and Ligue R{\'e}gionale contre le Cancer (C.D.). Funding Information: This research was funded by Ligue Nationale contre le Cancer (N.L.), the SIRIC-BRIO (N.L.), Fundation ARC (C.B.), Canc?rop?le Grand Sud-Ouest (C.D.) and Ligue R?gionale contre le Cancer (C.D.). Publisher Copyright: {\textcopyright} 2022 by the authors.",

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doi = "10.3390/cells11030554",

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T2 - Clinical Perspectives

AU - Boyer, Thomas

AU - Blaye, Céline

AU - Larmonier, Nicolas

AU - Domblides, Charlotte

N1 - Funding Information: Funding: This research was funded by Ligue Nationale contre le Cancer (N.L.), the SIRIC-BRIO (N.L.), Fundation ARC (C.B.), Cancéropôle Grand Sud-Ouest (C.D.) and Ligue Régionale contre le Cancer (C.D.). Funding Information: This research was funded by Ligue Nationale contre le Cancer (N.L.), the SIRIC-BRIO (N.L.), Fundation ARC (C.B.), Canc?rop?le Grand Sud-Ouest (C.D.) and Ligue R?gionale contre le Cancer (C.D.). Publisher Copyright: © 2022 by the authors.

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N2 - Tumor metabolism plays a crucial role in sustaining tumorigenesis. There have been increasing reports regarding the role of tumor metabolism in the control of immune cell functions, generating a potent immunosuppressive contexture that can lead to immune escape. The metabolic reprogramming of tumor cells and the immune escape are two major hallmarks of cancer, with several instances of crosstalk between them. In this paper, we review the effects of tumor metabolism on immune cells, focusing on myeloid cells due to their important role in tumorigenesis and immunosuppression from the early stages of the disease. We also discuss ways to target this specific crosstalk in cancer patients.

AB - Tumor metabolism plays a crucial role in sustaining tumorigenesis. There have been increasing reports regarding the role of tumor metabolism in the control of immune cell functions, generating a potent immunosuppressive contexture that can lead to immune escape. The metabolic reprogramming of tumor cells and the immune escape are two major hallmarks of cancer, with several instances of crosstalk between them. In this paper, we review the effects of tumor metabolism on immune cells, focusing on myeloid cells due to their important role in tumorigenesis and immunosuppression from the early stages of the disease. We also discuss ways to target this specific crosstalk in cancer patients.

KW - Cancer

KW - Immunomodulation

KW - Immunotherapy

KW - Macrophages

KW - Metabolism

KW - Myeloid cells

KW - Myeloid-derived suppressive cells

KW - Therapeutic strategies

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Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives

Abstract

Keywords

ASJC Scopus subject areas

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