Integrating nanooptical biosensors into nucleic acid testing devices

Qi Huo Wei, Jian Gu, Chia Fu Chou, Frederic Zenhausern

Research output: Contribution to journalConference articlepeer-review


Nano optical biosensors employ the interaction between biomolecules and light confined in nanometer scale structures to report the bio-recognition events. This small scale sensing area/volume can ensure that small amount of biorecognition events could be detected. The exceptional sensitivity and high spatial density of nano optical biosensors make them unique in practical applications in nucleic acid detection. Lab-on-a-Chip systems provide the capabilities of separation, cell lysing, polymerase chain reaction (PCR), allowing finishing bio agent detection processes on a chip. In this paper, we present our recent efforts on integrating some novel nanooptical biosensors into Lab-on-a-Chip systems and some preliminary test results.

Original languageEnglish (US)
Pages (from-to)45-53
Number of pages9
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2004
EventEmerging Optoelectronic Applications - San Jose, CA, United States
Duration: Jan 26 2004Jan 27 2004


  • Nano Optical Biosensors
  • Nucleic acid based bioprobes
  • Surface Plasmon Resonance

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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