Intrinsic and extrinsic contributors to defective CD8+ T cell responses with aging

Mladen Jergović, Megan J. Smithey, Janko Nikolich-Žugich

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Aging has a profound effect on the immune system, and both innate and adaptive arms of the immune system show functional decline with age. In response to infection with intracellular microorganisms, old animals mobilize decreased numbers of antigen-specific CD8+ T cells with reduced production of effector molecules and impaired cytolytic activity. However, the CD8+ T cell-intrinsic contribution to, and molecular mechanisms behind, these defects remain unclear. In this review we will discuss the mechanistic contributions of age related changes in the CD8+ T cell pool and the relative roles of intrinsic functional defects in aged CD8+ T cells vs. defects in the aged environment initiating the CD8+ T cell response.

Original languageEnglish (US)
Pages (from-to)140-145
Number of pages6
JournalExperimental Gerontology
StatePublished - May 2018

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology


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