Isolation and characterization of a presumed biosynthetic precursor of camptothecin from extracts of Camptotheca acuminata

Brad K. Carte; Charles DeBrosse; Drake Eggleston; Mark Hemling; Mary Mentzer; Benjamin Poehland; Nelson Troupe; John W. Westley; Sidney M. Hecht

doi:10.1016/S0040-4020(01)88369-1

Isolation and characterization of a presumed biosynthetic precursor of camptothecin from extracts of Camptotheca acuminata

Brad K. Carte
, Charles DeBrosse
, Drake Eggleston
, Mark Hemling
, Mary Mentzer
, Benjamin Poehland
, Nelson Troupe
, John W. Westley
, Sidney M. Hecht

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

A biosynthetic precursor 4 of the antitumor alkaloid camptothecin (1) has been isolated from alkaloid enriched extracts of Camptotheca acuminata. The structure of 4, which was determined both in the solid state by x-ray diffraction and in solution by NMR analysis, provides strong evidence in support of the proposed biosynthetic scheme for camptothecin (1).

Original language	English (US)
Pages (from-to)	2747-2760
Number of pages	14
Journal	Tetrahedron
Volume	46
Issue number	8
DOIs	https://doi.org/10.1016/S0040-4020(01)88369-1
State	Published - 1990
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4020(01)88369-1

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title = "Isolation and characterization of a presumed biosynthetic precursor of camptothecin from extracts of Camptotheca acuminata",

abstract = "A biosynthetic precursor 4 of the antitumor alkaloid camptothecin (1) has been isolated from alkaloid enriched extracts of Camptotheca acuminata. The structure of 4, which was determined both in the solid state by x-ray diffraction and in solution by NMR analysis, provides strong evidence in support of the proposed biosynthetic scheme for camptothecin (1).",

author = "Carte, \{Brad K.\} and Charles DeBrosse and Drake Eggleston and Mark Hemling and Mary Mentzer and Benjamin Poehland and Nelson Troupe and Westley, \{John W.\} and Hecht, \{Sidney M.\}",

year = "1990",

doi = "10.1016/S0040-4020(01)88369-1",

language = "English (US)",

volume = "46",

pages = "2747--2760",

journal = "Tetrahedron",

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T1 - Isolation and characterization of a presumed biosynthetic precursor of camptothecin from extracts of Camptotheca acuminata

AU - Carte, Brad K.

AU - DeBrosse, Charles

AU - Eggleston, Drake

AU - Hemling, Mark

AU - Mentzer, Mary

AU - Poehland, Benjamin

AU - Troupe, Nelson

AU - Westley, John W.

AU - Hecht, Sidney M.

PY - 1990

Y1 - 1990

N2 - A biosynthetic precursor 4 of the antitumor alkaloid camptothecin (1) has been isolated from alkaloid enriched extracts of Camptotheca acuminata. The structure of 4, which was determined both in the solid state by x-ray diffraction and in solution by NMR analysis, provides strong evidence in support of the proposed biosynthetic scheme for camptothecin (1).

AB - A biosynthetic precursor 4 of the antitumor alkaloid camptothecin (1) has been isolated from alkaloid enriched extracts of Camptotheca acuminata. The structure of 4, which was determined both in the solid state by x-ray diffraction and in solution by NMR analysis, provides strong evidence in support of the proposed biosynthetic scheme for camptothecin (1).

UR - https://www.scopus.com/pages/publications/0025237414

UR - https://www.scopus.com/pages/publications/0025237414#tab=citedBy

U2 - 10.1016/S0040-4020(01)88369-1

DO - 10.1016/S0040-4020(01)88369-1

M3 - Article

SN - 0040-4020

VL - 46

SP - 2747

EP - 2760

JO - Tetrahedron

JF - Tetrahedron

IS - 8

ER -

Isolation and characterization of a presumed biosynthetic precursor of camptothecin from extracts of Camptotheca acuminata

Abstract

ASJC Scopus subject areas

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