@inproceedings{254fc8b302ee420abbe0cbc623728db1,
title = "Lung function and pulmonary biomarkers in children chronically exposed to arsenic in drinking water",
abstract = "The objective of this study was to determine whether arsenic exposure is associated with changes in biomarkers of lung inflammation measured by the ratio of metalloproteinase 9 (MMP-9)/tissue inhibitor of metalloproteinase (TIMP-1), levels of soluble form of Receptor for Advanced Glycation End products (RAGE) in sputum and with decreased lung capacity. Tap water of communities and first morning void urine were analyzed for arsenic. Arsenic levels in this region are 50-120 μg/L in drinking water. Total arsenic urinary (median) was higher in subjects with restrictive spirometric patterns than normal spirometric patterns subjects (123.7 vs. 92.9) (p < 0.05). In addition, we observed significantly decreased in ratio MMP-9/TIMP1 and RAGE levels [median (range)] in subjects with restrictive spirometric patterns in comparison with subjects normal [23.21 (17.5, 37.4) vs. 9.0 (3.5,16.4)] and [46.7 (34.4-71.3) vs. 31.2 (20.3-43.2)] respectively. This finding suggests a potential toxic mechanism in lung for arsenic exposure.",
author = "{Olivas Calder{\'o}n}, {E. H.} and {Espinosa Fematt}, {J. A.} and {Recio Vega}, R. and {Ocampo G{\'o}mez}, G. and {Cortes Gonz{\'a}lez}, T. and Lantz, {R. C.} and Gandolfi, {A. J.}",
year = "2014",
doi = "10.1201/b16767-214",
language = "English (US)",
isbn = "9781138001411",
series = "One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment",
publisher = "CRC Press/Balkema",
pages = "578--579",
booktitle = "One Century of the Discovery of Arsenicosis in Latin America (1914-2014)",
note = "5th International Congress on Arsenic in the Environment, As 2014 ; Conference date: 11-05-2014 Through 16-05-2014",
}