Measuring Extracellular pH in a Lung Fibrosis Model with acidoCEST MRI

Kyle M. Jones; Edward A. Randtke; Christine M. Howison; Julio Cárdenas-Rodríguez; Patricia J. Sime; Matthew R. Kottmann; Mark D. Pagel

doi:10.1007/s11307-014-0784-6

Measuring Extracellular pH in a Lung Fibrosis Model with acidoCEST MRI

Kyle M. Jones
, Edward A. Randtke
, Christine M. Howison
, Julio Cárdenas-Rodríguez
, Patricia J. Sime
, Matthew R. Kottmann
, Mark D. Pagel

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Purpose: A feed-forward loop involving lactic acid production may potentially occur during the formation of idiopathic pulmonary fibrosis. To provide evidence for this feed-forward loop, we used acidoCEST MRI to measure the extracellular pH (pHe), while also measuring percent uptake of the contrast agent, lesion size, and the apparent diffusion coefficient (ADC).Procedures: We developed a respiration-gated version of acidoCEST MRI to improve the measurement of pHe and percent uptake in lesions. We also used T₂-weighted MRI to measure lesion volumes and diffusion-weighted MRI to measure ADC.Results: The longitudinal changes in average pHe and % uptake of the contrast agent were inversely related to reduction in lung lesion volume. The average ADC did not change during the time frame of the study.Conclusions:

Original language	English (US)
Pages (from-to)	177-184
Number of pages	8
Journal	Molecular Imaging and Biology
Volume	17
Issue number	2
DOIs	https://doi.org/10.1007/s11307-014-0784-6
State	Published - Apr 2015

Keywords

CEST
Idiopathic pulmonary fibrosis
MRI
pH

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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10.1007/s11307-014-0784-6

Cite this

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title = "Measuring Extracellular pH in a Lung Fibrosis Model with acidoCEST MRI",

abstract = "Purpose: A feed-forward loop involving lactic acid production may potentially occur during the formation of idiopathic pulmonary fibrosis. To provide evidence for this feed-forward loop, we used acidoCEST MRI to measure the extracellular pH (pHe), while also measuring percent uptake of the contrast agent, lesion size, and the apparent diffusion coefficient (ADC).Procedures: We developed a respiration-gated version of acidoCEST MRI to improve the measurement of pHe and percent uptake in lesions. We also used T2-weighted MRI to measure lesion volumes and diffusion-weighted MRI to measure ADC.Results: The longitudinal changes in average pHe and \% uptake of the contrast agent were inversely related to reduction in lung lesion volume. The average ADC did not change during the time frame of the study.Conclusions:",

keywords = "CEST, Idiopathic pulmonary fibrosis, MRI, pH",

author = "Jones, \{Kyle M.\} and Randtke, \{Edward A.\} and Howison, \{Christine M.\} and Julio C{\'a}rdenas-Rodr{\'i}guez and Sime, \{Patricia J.\} and Kottmann, \{Matthew R.\} and Pagel, \{Mark D.\}",

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doi = "10.1007/s11307-014-0784-6",

language = "English (US)",

volume = "17",

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TY - JOUR

T1 - Measuring Extracellular pH in a Lung Fibrosis Model with acidoCEST MRI

AU - Jones, Kyle M.

AU - Randtke, Edward A.

AU - Howison, Christine M.

AU - Cárdenas-Rodríguez, Julio

AU - Sime, Patricia J.

AU - Kottmann, Matthew R.

AU - Pagel, Mark D.

PY - 2015/4

Y1 - 2015/4

N2 - Purpose: A feed-forward loop involving lactic acid production may potentially occur during the formation of idiopathic pulmonary fibrosis. To provide evidence for this feed-forward loop, we used acidoCEST MRI to measure the extracellular pH (pHe), while also measuring percent uptake of the contrast agent, lesion size, and the apparent diffusion coefficient (ADC).Procedures: We developed a respiration-gated version of acidoCEST MRI to improve the measurement of pHe and percent uptake in lesions. We also used T2-weighted MRI to measure lesion volumes and diffusion-weighted MRI to measure ADC.Results: The longitudinal changes in average pHe and % uptake of the contrast agent were inversely related to reduction in lung lesion volume. The average ADC did not change during the time frame of the study.Conclusions:

AB - Purpose: A feed-forward loop involving lactic acid production may potentially occur during the formation of idiopathic pulmonary fibrosis. To provide evidence for this feed-forward loop, we used acidoCEST MRI to measure the extracellular pH (pHe), while also measuring percent uptake of the contrast agent, lesion size, and the apparent diffusion coefficient (ADC).Procedures: We developed a respiration-gated version of acidoCEST MRI to improve the measurement of pHe and percent uptake in lesions. We also used T2-weighted MRI to measure lesion volumes and diffusion-weighted MRI to measure ADC.Results: The longitudinal changes in average pHe and % uptake of the contrast agent were inversely related to reduction in lung lesion volume. The average ADC did not change during the time frame of the study.Conclusions:

KW - CEST

KW - Idiopathic pulmonary fibrosis

KW - MRI

KW - pH

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UR - https://www.scopus.com/pages/publications/84924534980#tab=citedBy

U2 - 10.1007/s11307-014-0784-6

DO - 10.1007/s11307-014-0784-6

M3 - Article

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SN - 1536-1632

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SP - 177

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JO - Molecular Imaging and Biology

JF - Molecular Imaging and Biology

IS - 2

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Measuring Extracellular pH in a Lung Fibrosis Model with acidoCEST MRI

Abstract

Keywords

ASJC Scopus subject areas

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