Metabolomic Patterns Observed among Children with Autism Spectrum Disorder following Vitamin/Mineral Supplementation

Fatir A. Qureshi, James B. Adams, Juergen Hahn

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

While the etiology and mechanisms underpinning the pathogenesis of autism spectrum disorder (ASD) continue to be under investigation, identifying unique metabolomic patterns in children with ASD is one promising avenue. Re-examining the data collected from a nutritional supplementation study on a cohort of children with ASD, this work seeks to better elucidate the mechanisms behind how nutritional intervention impacts changes in recipients' behavior and underlying metabolomics. Among biochemical measurements that were identified at baseline as being significant distinct between typically developing and ASD cohorts, 50% no longer significantly differed after intervention. Furthermore, among the correlational relationships observed, nutritional intervention was associated with a shift towards correlations between metabolites more like that of a comparable typically developing cohort.

Original languageEnglish (US)
Title of host publicationIFAC-PapersOnLine
EditorsMaria Klapa, Daniel P. Howsmon, Ioannis P. Androulakis
PublisherElsevier B.V.
Pages156-160
Number of pages5
Edition23
ISBN (Electronic)9781713867890
DOIs
StatePublished - Sep 1 2022
Event9th IFAC Conference on Foundations of Systems Biology in Engineering, FOSBE 2022 - Cambridge, United States
Duration: Aug 28 2022Aug 31 2022

Publication series

NameIFAC-PapersOnLine
Number23
Volume55

Conference

Conference9th IFAC Conference on Foundations of Systems Biology in Engineering, FOSBE 2022
Country/TerritoryUnited States
CityCambridge
Period8/28/228/31/22

Keywords

  • ASD
  • Differential Network Analysis
  • Statistical Analysis

ASJC Scopus subject areas

  • Control and Systems Engineering

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