MicroRNA-mediated regulation of differentiation and trans-differentiation in stem cells

Sang Ging Ong; Won Hee Lee; Kazuki Kodo; Joseph C. Wu

doi:10.1016/j.addr.2015.04.004

MicroRNA-mediated regulation of differentiation and trans-differentiation in stem cells

Sang Ging Ong, Won Hee Lee, Kazuki Kodo, Joseph C. Wu

Research output: Contribution to journal › Review article › peer-review

57 Scopus citations

Abstract

MicroRNAs (miRNAs) are key components of a broadly conserved post-transcriptional mechanism that controls gene expression by targeting mRNAs. miRNAs regulate diverse biological processes, including the growth and differentiation of stem cells as well as the regulation of both endogenous tissue repair that has critical implications in the development of regenerative medicine approaches. In this review, we first describe key features of miRNA biogenesis and their role in regulating self-renewal, and then discuss the involvement of miRNAs in the determination of cell fate decisions. We highlight the role of miRNAs in the emergent field of reprogramming and trans-differentiation of somatic cells that could further our understanding of miRNA biology and regenerative medicine applications. Finally, we describe potential techniques for proper delivery of miRNAs in target cells.

Original language	English (US)
Pages (from-to)	3-15
Number of pages	13
Journal	Advanced Drug Delivery Reviews
Volume	88
DOIs	https://doi.org/10.1016/j.addr.2015.04.004
State	Published - Jul 1 2015
Externally published	Yes

Keywords

Differentiation
MicroRNAs
Regenerative medicine
Reprogramming
Self-renewal
Trans-differentiation

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/j.addr.2015.04.004

Cite this

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title = "MicroRNA-mediated regulation of differentiation and trans-differentiation in stem cells",

abstract = "MicroRNAs (miRNAs) are key components of a broadly conserved post-transcriptional mechanism that controls gene expression by targeting mRNAs. miRNAs regulate diverse biological processes, including the growth and differentiation of stem cells as well as the regulation of both endogenous tissue repair that has critical implications in the development of regenerative medicine approaches. In this review, we first describe key features of miRNA biogenesis and their role in regulating self-renewal, and then discuss the involvement of miRNAs in the determination of cell fate decisions. We highlight the role of miRNAs in the emergent field of reprogramming and trans-differentiation of somatic cells that could further our understanding of miRNA biology and regenerative medicine applications. Finally, we describe potential techniques for proper delivery of miRNAs in target cells.",

keywords = "Differentiation, MicroRNAs, Regenerative medicine, Reprogramming, Self-renewal, Trans-differentiation",

author = "Ong, {Sang Ging} and Lee, {Won Hee} and Kazuki Kodo and Wu, {Joseph C.}",

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doi = "10.1016/j.addr.2015.04.004",

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T1 - MicroRNA-mediated regulation of differentiation and trans-differentiation in stem cells

AU - Ong, Sang Ging

AU - Lee, Won Hee

AU - Kodo, Kazuki

AU - Wu, Joseph C.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - MicroRNAs (miRNAs) are key components of a broadly conserved post-transcriptional mechanism that controls gene expression by targeting mRNAs. miRNAs regulate diverse biological processes, including the growth and differentiation of stem cells as well as the regulation of both endogenous tissue repair that has critical implications in the development of regenerative medicine approaches. In this review, we first describe key features of miRNA biogenesis and their role in regulating self-renewal, and then discuss the involvement of miRNAs in the determination of cell fate decisions. We highlight the role of miRNAs in the emergent field of reprogramming and trans-differentiation of somatic cells that could further our understanding of miRNA biology and regenerative medicine applications. Finally, we describe potential techniques for proper delivery of miRNAs in target cells.

AB - MicroRNAs (miRNAs) are key components of a broadly conserved post-transcriptional mechanism that controls gene expression by targeting mRNAs. miRNAs regulate diverse biological processes, including the growth and differentiation of stem cells as well as the regulation of both endogenous tissue repair that has critical implications in the development of regenerative medicine approaches. In this review, we first describe key features of miRNA biogenesis and their role in regulating self-renewal, and then discuss the involvement of miRNAs in the determination of cell fate decisions. We highlight the role of miRNAs in the emergent field of reprogramming and trans-differentiation of somatic cells that could further our understanding of miRNA biology and regenerative medicine applications. Finally, we describe potential techniques for proper delivery of miRNAs in target cells.

KW - Differentiation

KW - MicroRNAs

KW - Regenerative medicine

KW - Reprogramming

KW - Self-renewal

KW - Trans-differentiation

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DO - 10.1016/j.addr.2015.04.004

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EP - 15

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

ER -

MicroRNA-mediated regulation of differentiation and trans-differentiation in stem cells

Abstract

Keywords

ASJC Scopus subject areas

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