@inproceedings{b8bf8ea5f67a47c89abfa0beae44b247,
title = "Microscale transport physics during atomic force microscopy mass spectrometry and improved sampling efficiency",
abstract = "This paper reports improvements of atomic force microscopy (AFM) mass spectrometry (MS), in which ∼1 attoliter of analyte is desorbed by a heated AFM cantilever tip and analyzed with a mass spectrometer. Decoupling the AFM sampling apparatus from the MS system enabled analysis of the microscale transport physics independent of analyte ionization efficiency. Using this approach, we find that the transport efficiency is governed by the air velocity during sampling, and not mass flow rate as reported in the literature. We also find that an unheated sampling tube results in higher efficiency compared to a heated tube. Optimization of the transport parameters improved the system efficiency by 2.5-fold over the state of the art.",
keywords = "Atomic force microscopy, heated cantilever, mass spectrometry, thermal desorption, transport physics",
author = "Hyunkyu Moon and Comi, {Troy J.} and Dunham, {Sage J.B.} and Beomjin Kwon and Sweedler, {Jonathan V.} and King, {William P.}",
note = "Funding Information: We thank Dr. Craig Prater at Anasys Instruments for valuable discussions. JVS acknowledges support through NSF CHE 16-067915. Publisher Copyright: {\textcopyright} 2017 IEEE. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.; 19th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2017 ; Conference date: 18-06-2017 Through 22-06-2017",
year = "2017",
month = jul,
day = "26",
doi = "10.1109/TRANSDUCERS.2017.7993978",
language = "English (US)",
series = "TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "24--27",
booktitle = "TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems",
}