TY - JOUR
T1 - Montagnuphilones a-g, azaphilones from Montagnulaceae sp. DM0194, a fungal endophyte of submerged roots of Persicaria amphibia
AU - Luo, Jian Guang
AU - Xu, Ya Ming
AU - Sandberg, Dustin C.
AU - Arnold, A. Elizabeth
AU - Gunatilaka, A. A.Leslie
N1 - Funding Information: Financial support for this work was provided by Grant R01 CA090265 funded by the National Cancer Institute (NCI) and Grant P41 GM094060 funded by National Institute of General Medical Sciences (NIGMS). We thank China Scholarship Council for awarding a Postdoctoral Fellowship (to J.-G.L.) and L. Battista and P. Espinosa-Artiles respectively for their assistance in collecting plant material in the field and largescale culturing of the fungal strain. Publisher Copyright: © 2017 American Chemical Society and American Society of Pharmacognosy.
PY - 2017/1/27
Y1 - 2017/1/27
N2 - Seven azaphilones, montagnuphilones A.G (1.7), together with previously known azaphilones 8.11, were encountered in Montagnulaceae sp. DM0194, an endophytic fungus isolated from submerged roots of Persicaria amphibia. The structures of 1.7 were elucidated on the basis of their MS and NMR spectroscopic analysis. Compounds 1.8 were evaluated for their cytotoxicity and ability to inhibit nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophage cells. Among these, none were found to be cytotoxic to RAW264.7 cells up to 100.0 μM, but 8, 5, and 2 showed NO inhibitory activity with IC50 values of 9.2 ± 0.9, 25.5 ± 1.1, and 39.6 ± 1.8 μM, respectively.
AB - Seven azaphilones, montagnuphilones A.G (1.7), together with previously known azaphilones 8.11, were encountered in Montagnulaceae sp. DM0194, an endophytic fungus isolated from submerged roots of Persicaria amphibia. The structures of 1.7 were elucidated on the basis of their MS and NMR spectroscopic analysis. Compounds 1.8 were evaluated for their cytotoxicity and ability to inhibit nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophage cells. Among these, none were found to be cytotoxic to RAW264.7 cells up to 100.0 μM, but 8, 5, and 2 showed NO inhibitory activity with IC50 values of 9.2 ± 0.9, 25.5 ± 1.1, and 39.6 ± 1.8 μM, respectively.
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U2 - 10.1021/acs.jnatprod.6b00714
DO - 10.1021/acs.jnatprod.6b00714
M3 - Article
C2 - 28099011
SN - 0163-3864
VL - 80
SP - 76
EP - 81
JO - Journal Of Natural Products
JF - Journal Of Natural Products
IS - 1
ER -