Mycoleptodiscins A and B, cytotoxic alkaloids from the endophytic fungus Mycoleptodiscus sp. F0194

Humberto E. Ortega; Paul R. Graupner; Yumi Asai; Karen Tendyke; Dayong Qiu; Young Yongchun Shen; Nivia Rios; A. Elizabeth Arnold; Phyllis D. Coley; Thomas A. Kursar; William H. Gerwick; Luis Cubilla-Rios

doi:10.1021/np300792t

Mycoleptodiscins A and B, cytotoxic alkaloids from the endophytic fungus Mycoleptodiscus sp. F0194

Humberto E. Ortega, Paul R. Graupner, Yumi Asai, Karen Tendyke, Dayong Qiu, Young Yongchun Shen, Nivia Rios, A. Elizabeth Arnold, Phyllis D. Coley, Thomas A. Kursar, William H. Gerwick, Luis Cubilla-Rios

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Two novel reddish-orange alkaloids, mycoleptodiscin A (1) and mycoleptodiscin B (2), were isolated from liquid cultures of the endophytic fungus Mycoleptodiscus sp. that had been isolated from Desmotes incomparabilis in Panama. Elucidation of their structures was accomplished using 1D and 2D NMR spectroscopy in combination with IR spectroscopic and MS data. These compounds are indole-terpenes with a new skeleton uncommon in nature. Mycoleptodiscin B (2) was active in inhibiting the growth of cancer cell lines with IC ₅₀ values in the range 0.60-0.78 μM.

Original language	English (US)
Pages (from-to)	741-744
Number of pages	4
Journal	Journal Of Natural Products
Volume	76
Issue number	4
DOIs	https://doi.org/10.1021/np300792t
State	Published - Apr 26 2013

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Mycoleptodiscins A and B, cytotoxic alkaloids from the endophytic fungus Mycoleptodiscus sp. F0194",

abstract = "Two novel reddish-orange alkaloids, mycoleptodiscin A (1) and mycoleptodiscin B (2), were isolated from liquid cultures of the endophytic fungus Mycoleptodiscus sp. that had been isolated from Desmotes incomparabilis in Panama. Elucidation of their structures was accomplished using 1D and 2D NMR spectroscopy in combination with IR spectroscopic and MS data. These compounds are indole-terpenes with a new skeleton uncommon in nature. Mycoleptodiscin B (2) was active in inhibiting the growth of cancer cell lines with IC 50 values in the range 0.60-0.78 μM.",

author = "Ortega, {Humberto E.} and Graupner, {Paul R.} and Yumi Asai and Karen Tendyke and Dayong Qiu and Shen, {Young Yongchun} and Nivia Rios and Arnold, {A. Elizabeth} and Coley, {Phyllis D.} and Kursar, {Thomas A.} and Gerwick, {William H.} and Luis Cubilla-Rios",

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doi = "10.1021/np300792t",

language = "English (US)",

volume = "76",

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T1 - Mycoleptodiscins A and B, cytotoxic alkaloids from the endophytic fungus Mycoleptodiscus sp. F0194

AU - Ortega, Humberto E.

AU - Graupner, Paul R.

AU - Asai, Yumi

AU - Tendyke, Karen

AU - Qiu, Dayong

AU - Shen, Young Yongchun

AU - Rios, Nivia

AU - Arnold, A. Elizabeth

AU - Coley, Phyllis D.

AU - Kursar, Thomas A.

AU - Gerwick, William H.

AU - Cubilla-Rios, Luis

PY - 2013/4/26

Y1 - 2013/4/26

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AB - Two novel reddish-orange alkaloids, mycoleptodiscin A (1) and mycoleptodiscin B (2), were isolated from liquid cultures of the endophytic fungus Mycoleptodiscus sp. that had been isolated from Desmotes incomparabilis in Panama. Elucidation of their structures was accomplished using 1D and 2D NMR spectroscopy in combination with IR spectroscopic and MS data. These compounds are indole-terpenes with a new skeleton uncommon in nature. Mycoleptodiscin B (2) was active in inhibiting the growth of cancer cell lines with IC 50 values in the range 0.60-0.78 μM.

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Mycoleptodiscins A and B, cytotoxic alkaloids from the endophytic fungus Mycoleptodiscus sp. F0194

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