TY - JOUR
T1 - Myeloid-derived suppressor cells in gastrointestinal cancers
T2 - A systemic review
AU - Farshidpour, Maham
AU - Ahmed, Monjur
AU - Junna, Shilpa
AU - Merchant, Juanita L.
N1 - Publisher Copyright: © 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Gastrointestinal (GI) cancers are one of the most common malignancies worldwide, with high rates of morbidity and mortality. Myeloid-derived suppressor cells (MDSCs) are major components of the tumor microenvironment (TME). MDSCs facilitate the transformation of premalignant cells and play roles in tumor growth and metastasis. Moreover, in patients with GI malignancies, MDSCs can lead to the suppression of T cells and natural killer cells. Accordingly, a better understanding of the role and mechanism of action of MDSCs in the TME will aid in the development of novel immune-targeted therapies.
AB - Gastrointestinal (GI) cancers are one of the most common malignancies worldwide, with high rates of morbidity and mortality. Myeloid-derived suppressor cells (MDSCs) are major components of the tumor microenvironment (TME). MDSCs facilitate the transformation of premalignant cells and play roles in tumor growth and metastasis. Moreover, in patients with GI malignancies, MDSCs can lead to the suppression of T cells and natural killer cells. Accordingly, a better understanding of the role and mechanism of action of MDSCs in the TME will aid in the development of novel immune-targeted therapies.
KW - Gastrointestinal cancers
KW - Immune checkpoint inhibitors
KW - Myeloid-derived suppressor cells
KW - Tumor progression
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U2 - 10.4251/WJGO.V13.I1.1
DO - 10.4251/WJGO.V13.I1.1
M3 - Article
SN - 1948-5204
VL - 13
SP - 1
EP - 15
JO - World Journal of Gastrointestinal Oncology
JF - World Journal of Gastrointestinal Oncology
IS - 1
ER -