TY - CHAP
T1 - Neuroinflammation and Tinnitus
AU - Shulman, Abraham
AU - Wang, Weihua
AU - Luo, Hao
AU - Bao, Shaowen
AU - Searchfield, Grant
AU - Zhang, Jinsheng
N1 - Funding Information: Acknowledgements This work was supported by the US Department of Defense (W81XWH-15-1-0028, W81XWH-15-1-0356, W81XWH-15-1-0357) and Martha Entenmann Tinnitus Research Center. The support of Richard M. Rosenfeld, M.D., and Matthew B. Hanson M.D. in tinnitus interest and efforts is appreciated. Publisher Copyright: © 2021, Springer Nature Switzerland AG.
PY - 2021
Y1 - 2021
N2 - Neuroinflammation is the central nervous system’s response to: injury, infection, and abnormal neural activity. Inflammatory processes are known to mediate many diseases, and recently evidence indicates that neuroinflammation underlies hearing disorders such as presbyacusis, middle-ear disease, ototoxicity, noise-induced hearing loss, and tinnitus. This chapter provides a review of the role of neuroinflammation in the etiology and treatment of tinnitus. Specifically, our research team has demonstrated that both tumor necrosis factor alpha (TNF-α) and calpain signaling pathways are involved in noise-induced tinnitus and that blocking them yielded therapeutic effects on tinnitus. Other efforts such as controlling acute inflammatory response via specialized pro-resolving mediators may help provide insight into preventing and treating tinnitus-related inflammatory processes.
AB - Neuroinflammation is the central nervous system’s response to: injury, infection, and abnormal neural activity. Inflammatory processes are known to mediate many diseases, and recently evidence indicates that neuroinflammation underlies hearing disorders such as presbyacusis, middle-ear disease, ototoxicity, noise-induced hearing loss, and tinnitus. This chapter provides a review of the role of neuroinflammation in the etiology and treatment of tinnitus. Specifically, our research team has demonstrated that both tumor necrosis factor alpha (TNF-α) and calpain signaling pathways are involved in noise-induced tinnitus and that blocking them yielded therapeutic effects on tinnitus. Other efforts such as controlling acute inflammatory response via specialized pro-resolving mediators may help provide insight into preventing and treating tinnitus-related inflammatory processes.
KW - Inflammatopathy
KW - Microglia specific pro-resolving mediator
KW - Neuroinflammation
KW - Tumor necrosis factor alpha (TNF-α) calpain
UR - http://www.scopus.com/inward/record.url?scp=85114310135&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85114310135&partnerID=8YFLogxK
U2 - 10.1007/7854_2021_238
DO - 10.1007/7854_2021_238
M3 - Chapter
C2 - 34282564
T3 - Current Topics in Behavioral Neurosciences
SP - 161
EP - 174
BT - Current Topics in Behavioral Neurosciences
PB - Springer Science and Business Media Deutschland GmbH
ER -