TY - JOUR
T1 - Neuropeptides and peptide hormones in Anopheles gambiae
AU - Riehle, Michael A.
AU - Garczynski, Stephen F.
AU - Crim, Joe W.
AU - Hill, Catherine A.
AU - Brown, Mark R.
PY - 2002/10/4
Y1 - 2002/10/4
N2 - The African malaria mosquito, Anopheles gambiae, is specialized for rapid completion of development and reproduction. A vertebrate blood meal is required for egg production, and multiple feedings subsequently allow transmission of malaria parasites, Plasmodium spp. Regulatory peptides from 35 genes annotated from the A. gambiae genome likely coordinate these and other physiological processes. Plasmodium parasites may affect actions of newly identified insulin-like peptides, which coordinate growth and reproduction of its vector, A. gambiae, as in Drosophila melanogaster, Caenorhabditis elegans, and mammals. This genomic information provides a basis to expand understanding of hematophagy and pathogen transmission in this mosquito.
AB - The African malaria mosquito, Anopheles gambiae, is specialized for rapid completion of development and reproduction. A vertebrate blood meal is required for egg production, and multiple feedings subsequently allow transmission of malaria parasites, Plasmodium spp. Regulatory peptides from 35 genes annotated from the A. gambiae genome likely coordinate these and other physiological processes. Plasmodium parasites may affect actions of newly identified insulin-like peptides, which coordinate growth and reproduction of its vector, A. gambiae, as in Drosophila melanogaster, Caenorhabditis elegans, and mammals. This genomic information provides a basis to expand understanding of hematophagy and pathogen transmission in this mosquito.
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U2 - 10.1126/science.1076827
DO - 10.1126/science.1076827
M3 - Article
C2 - 12364794
SN - 0036-8075
VL - 298
SP - 172
EP - 175
JO - Science
JF - Science
IS - 5591
ER -