TY - GEN
T1 - Notice of Removal
T2 - 2017 IEEE International Ultrasonics Symposium, IUS 2017
AU - Lin, Shengtao
AU - Shah, Anant
AU - Hernandez-Gil, Javier
AU - Stanziola, Antonio
AU - Harriss, Bethany
AU - Matsunaga, Terry
AU - Long, Nicholas
AU - Bamber, Jeffrey
AU - Tang, Meng Xing
N1 - Funding Information: Shengtao Lin1, Anant Shah2, Javier Hernández-Gil3, Antonio Stanziola1, Bethany Harriss3, Terry Matsunaga4, Nicholas Long3, Jeffrey Bamber2, Meng-Xing Tang1;1Department of Bioengineering, Imperial College London, London, United Kingdom, 2Joint Department of Physics and Cancer Imaging Centre, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom, 3Department of Chemistry, Imperial College London, London, United Kingdom, 4Department of Medical Imaging, University of Arizona, Tucson, Arizona, USA Publisher Copyright: © 2017 IEEE.
PY - 2017/10/31
Y1 - 2017/10/31
N2 - To explore the extravascular space, sub-micron phase-change droplets show widespread interest in medical imaging and therapy with various modalities, such as ultrasound and photoacoustic. Existing studies (Wilson 2012, Wei 2014) on such dual-modality contrast agents have demonstrated the generation of both optical and ultrasound contrast after optical activation. However these studies did not explore the option of acoustic activation. Furthermore, high boiling point perfluorocarbons were used in these studies. A low boiling point may be preferred, to minimise un-wanted bioeffects, especially when activating in deeper tissues. In this study, we demonstrate a versatile phase-change sub-micron contrast agent that can provide three modes of contrast enhancement: 1) photoacoustic imaging contrast, 2) ultrasound contrast with optical activation, and 3) ultrasound contrast with acoustic activation. This would add versatility of vaporisation triggering, offering new possibilities in dual mode imaging, molecular imaging and drug delivery.
AB - To explore the extravascular space, sub-micron phase-change droplets show widespread interest in medical imaging and therapy with various modalities, such as ultrasound and photoacoustic. Existing studies (Wilson 2012, Wei 2014) on such dual-modality contrast agents have demonstrated the generation of both optical and ultrasound contrast after optical activation. However these studies did not explore the option of acoustic activation. Furthermore, high boiling point perfluorocarbons were used in these studies. A low boiling point may be preferred, to minimise un-wanted bioeffects, especially when activating in deeper tissues. In this study, we demonstrate a versatile phase-change sub-micron contrast agent that can provide three modes of contrast enhancement: 1) photoacoustic imaging contrast, 2) ultrasound contrast with optical activation, and 3) ultrasound contrast with acoustic activation. This would add versatility of vaporisation triggering, offering new possibilities in dual mode imaging, molecular imaging and drug delivery.
UR - http://www.scopus.com/inward/record.url?scp=85039448238&partnerID=8YFLogxK
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U2 - 10.1109/ULTSYM.2017.8092672
DO - 10.1109/ULTSYM.2017.8092672
M3 - Conference contribution
T3 - IEEE International Ultrasonics Symposium, IUS
BT - 2017 IEEE International Ultrasonics Symposium, IUS 2017
PB - IEEE Computer Society
Y2 - 6 September 2017 through 9 September 2017
ER -