One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases

Wesley C. Van Voorhis; Matthew A. Hulverson; Ryan Choi; Wenlin Huang; Samuel L.M. Arnold; Deborah A. Schaefer; Dana P. Betzer; Rama S.R. Vidadala; Sangun Lee; Grant R. Whitman; Lynn K. Barrett; Dustin J. Maly; Michael W. Riggs; Erkang Fan; Thomas J. Kennedy; Saul Tzipori; J. Stone Doggett; Pablo Winzer; Nicoleta Anghel; Dennis Imhof; Joachim Müller; Andrew Hemphill; Ignacio Ferre; Roberto Sanchez-Sanchez; Luis Miguel Ortega-Mora; Kayode K. Ojo

doi:10.1016/j.vetpar.2020.109336

One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases

Wesley C. Van Voorhis, Matthew A. Hulverson, Ryan Choi, Wenlin Huang, Samuel L.M. Arnold, Deborah A. Schaefer, Dana P. Betzer, Rama S.R. Vidadala, Sangun Lee, Grant R. Whitman, Lynn K. Barrett, Dustin J. Maly, Michael W. Riggs, Erkang Fan, Thomas J. Kennedy, Saul Tzipori, J. Stone Doggett, Pablo Winzer, Nicoleta Anghel, Dennis ImhofJoachim Müller, Andrew Hemphill, Ignacio Ferre, Roberto Sanchez-Sanchez, Luis Miguel Ortega-Mora, Kayode K. Ojo

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

This is a review of the development of bumped-kinase inhibitors (BKIs) for the therapy of One Health parasitic apicomplexan diseases. Many apicomplexan infections are shared between humans and livestock, such as cryptosporidiosis and toxoplasmosis, as well as livestock only diseases such as neosporosis. We have demonstrated proof-of-concept for BKI therapy in livestock models of cryptosporidiosis (newborn calves infected with Cryptosporidium parvum), toxoplasmosis (pregnant sheep infected with Toxoplasma gondii), and neosporosis (pregnant sheep infected with Neospora caninum). We discuss the potential uses of BKIs for the treatment of diseases caused by apicomplexan parasites in animals and humans, and the improvements that need to be made to further develop BKIs.

Original language	English (US)
Article number	109336
Journal	Veterinary Parasitology
Volume	289
DOIs	https://doi.org/10.1016/j.vetpar.2020.109336
State	Published - Jan 2021

Keywords

Antiparastics
Apicomplexa
Kinase inhibitors

ASJC Scopus subject areas

Parasitology
General Veterinary

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10.1016/j.vetpar.2020.109336

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Van Voorhis, W. C., Hulverson, M. A., Choi, R., Huang, W., Arnold, S. L. M., Schaefer, D. A., Betzer, D. P., Vidadala, R. S. R., Lee, S., Whitman, G. R., Barrett, L. K., Maly, D. J., Riggs, M. W., Fan, E., Kennedy, T. J., Tzipori, S., Doggett, J. S., Winzer, P., Anghel, N., ... Ojo, K. K. (2021). One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases. Veterinary Parasitology, 289, Article 109336. https://doi.org/10.1016/j.vetpar.2020.109336

Van Voorhis, WC, Hulverson, MA, Choi, R, Huang, W, Arnold, SLM, Schaefer, DA, Betzer, DP, Vidadala, RSR, Lee, S, Whitman, GR, Barrett, LK, Maly, DJ, Riggs, MW, Fan, E, Kennedy, TJ, Tzipori, S, Doggett, JS, Winzer, P, Anghel, N, Imhof, D, Müller, J, Hemphill, A, Ferre, I, Sanchez-Sanchez, R, Ortega-Mora, LM & Ojo, KK 2021, 'One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases', Veterinary Parasitology, vol. 289, 109336. https://doi.org/10.1016/j.vetpar.2020.109336

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title = "One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases",

abstract = "This is a review of the development of bumped-kinase inhibitors (BKIs) for the therapy of One Health parasitic apicomplexan diseases. Many apicomplexan infections are shared between humans and livestock, such as cryptosporidiosis and toxoplasmosis, as well as livestock only diseases such as neosporosis. We have demonstrated proof-of-concept for BKI therapy in livestock models of cryptosporidiosis (newborn calves infected with Cryptosporidium parvum), toxoplasmosis (pregnant sheep infected with Toxoplasma gondii), and neosporosis (pregnant sheep infected with Neospora caninum). We discuss the potential uses of BKIs for the treatment of diseases caused by apicomplexan parasites in animals and humans, and the improvements that need to be made to further develop BKIs.",

keywords = "Antiparastics, Apicomplexa, Kinase inhibitors",

author = "{Van Voorhis}, {Wesley C.} and Hulverson, {Matthew A.} and Ryan Choi and Wenlin Huang and Arnold, {Samuel L.M.} and Schaefer, {Deborah A.} and Betzer, {Dana P.} and Vidadala, {Rama S.R.} and Sangun Lee and Whitman, {Grant R.} and Barrett, {Lynn K.} and Maly, {Dustin J.} and Riggs, {Michael W.} and Erkang Fan and Kennedy, {Thomas J.} and Saul Tzipori and Doggett, {J. Stone} and Pablo Winzer and Nicoleta Anghel and Dennis Imhof and Joachim M{\"u}ller and Andrew Hemphill and Ignacio Ferre and Roberto Sanchez-Sanchez and Ortega-Mora, {Luis Miguel} and Ojo, {Kayode K.}",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2021",

month = jan,

doi = "10.1016/j.vetpar.2020.109336",

language = "English (US)",

volume = "289",

journal = "Veterinary Parasitology",

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AU - Van Voorhis, Wesley C.

AU - Hulverson, Matthew A.

AU - Choi, Ryan

AU - Huang, Wenlin

AU - Arnold, Samuel L.M.

AU - Schaefer, Deborah A.

AU - Betzer, Dana P.

AU - Vidadala, Rama S.R.

AU - Lee, Sangun

AU - Whitman, Grant R.

AU - Barrett, Lynn K.

AU - Maly, Dustin J.

AU - Riggs, Michael W.

AU - Fan, Erkang

AU - Kennedy, Thomas J.

AU - Tzipori, Saul

AU - Doggett, J. Stone

AU - Winzer, Pablo

AU - Anghel, Nicoleta

AU - Imhof, Dennis

AU - Müller, Joachim

AU - Hemphill, Andrew

AU - Ferre, Ignacio

AU - Sanchez-Sanchez, Roberto

AU - Ortega-Mora, Luis Miguel

AU - Ojo, Kayode K.

PY - 2021/1

Y1 - 2021/1

N2 - This is a review of the development of bumped-kinase inhibitors (BKIs) for the therapy of One Health parasitic apicomplexan diseases. Many apicomplexan infections are shared between humans and livestock, such as cryptosporidiosis and toxoplasmosis, as well as livestock only diseases such as neosporosis. We have demonstrated proof-of-concept for BKI therapy in livestock models of cryptosporidiosis (newborn calves infected with Cryptosporidium parvum), toxoplasmosis (pregnant sheep infected with Toxoplasma gondii), and neosporosis (pregnant sheep infected with Neospora caninum). We discuss the potential uses of BKIs for the treatment of diseases caused by apicomplexan parasites in animals and humans, and the improvements that need to be made to further develop BKIs.

AB - This is a review of the development of bumped-kinase inhibitors (BKIs) for the therapy of One Health parasitic apicomplexan diseases. Many apicomplexan infections are shared between humans and livestock, such as cryptosporidiosis and toxoplasmosis, as well as livestock only diseases such as neosporosis. We have demonstrated proof-of-concept for BKI therapy in livestock models of cryptosporidiosis (newborn calves infected with Cryptosporidium parvum), toxoplasmosis (pregnant sheep infected with Toxoplasma gondii), and neosporosis (pregnant sheep infected with Neospora caninum). We discuss the potential uses of BKIs for the treatment of diseases caused by apicomplexan parasites in animals and humans, and the improvements that need to be made to further develop BKIs.

KW - Antiparastics

KW - Apicomplexa

KW - Kinase inhibitors

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One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases

Abstract

Keywords

ASJC Scopus subject areas

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