Optimal and efficient designs for functional brain imaging experiments

Ching Shui Cheng; Ming-Hung Kao; Federick Kin Hing Phoa

doi:10.1016/j.jspi.2016.09.005

Optimal and efficient designs for functional brain imaging experiments

Ching Shui Cheng, Ming-Hung Kao, Federick Kin Hing Phoa

Mathematical and Statistical Sciences, School of (SoMSS)

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

This article concerns optimal experimental designs for neuroimaging studies in which the pioneering functional magnetic resonance imaging (fMRI) technology is used to investigate functions of the human brain. We develop analytical results for identifying designs that allow precise estimates of the contrasts between hemodynamic response functions (HRFs), each describing the effect of a mental stimulus over time. We also provide systematic methods for constructing optimal and very efficient designs, and show that fMRI designs obtained by relabeling the symbols of m-sequences can be very efficient in comparing the HRFs.

Original language	English (US)
Pages (from-to)	71-80
Number of pages	10
Journal	Journal of Statistical Planning and Inference
Volume	181
DOIs	https://doi.org/10.1016/j.jspi.2016.09.005
State	Published - Feb 1 2017

Keywords

Circulant orthogonal array
De Bruijn sequence
Hadamard sequence
Schur optimality
Type 1 criterion

ASJC Scopus subject areas

Statistics and Probability
Statistics, Probability and Uncertainty
Applied Mathematics

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10.1016/j.jspi.2016.09.005

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title = "Optimal and efficient designs for functional brain imaging experiments",

abstract = "This article concerns optimal experimental designs for neuroimaging studies in which the pioneering functional magnetic resonance imaging (fMRI) technology is used to investigate functions of the human brain. We develop analytical results for identifying designs that allow precise estimates of the contrasts between hemodynamic response functions (HRFs), each describing the effect of a mental stimulus over time. We also provide systematic methods for constructing optimal and very efficient designs, and show that fMRI designs obtained by relabeling the symbols of m-sequences can be very efficient in comparing the HRFs.",

keywords = "Circulant orthogonal array, De Bruijn sequence, Hadamard sequence, Schur optimality, Type 1 criterion",

author = "Cheng, {Ching Shui} and Ming-Hung Kao and Phoa, {Federick Kin Hing}",

note = "Funding Information: The research of Ming-Hung Kao was in part supported by National Science Foundation grants DMS-13-52213 , and DMS-15-02640 , and that of Frederick Kin Hing Phoa was in part supported by the Ministry of Science and Technology, Taiwan (project numbers: MOST-102-2628-M-001-002-MY3 , MOST-104-2118-M-001-016-MY2 , and MOST-105-2118-M-001-007-MY2 ), and by Academia Sinica (project number: AS-103-CDA-M04 ). Publisher Copyright: {\textcopyright} 2016 Elsevier B.V.",

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doi = "10.1016/j.jspi.2016.09.005",

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T1 - Optimal and efficient designs for functional brain imaging experiments

AU - Cheng, Ching Shui

AU - Kao, Ming-Hung

AU - Phoa, Federick Kin Hing

N1 - Funding Information: The research of Ming-Hung Kao was in part supported by National Science Foundation grants DMS-13-52213 , and DMS-15-02640 , and that of Frederick Kin Hing Phoa was in part supported by the Ministry of Science and Technology, Taiwan (project numbers: MOST-102-2628-M-001-002-MY3 , MOST-104-2118-M-001-016-MY2 , and MOST-105-2118-M-001-007-MY2 ), and by Academia Sinica (project number: AS-103-CDA-M04 ). Publisher Copyright: © 2016 Elsevier B.V.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - This article concerns optimal experimental designs for neuroimaging studies in which the pioneering functional magnetic resonance imaging (fMRI) technology is used to investigate functions of the human brain. We develop analytical results for identifying designs that allow precise estimates of the contrasts between hemodynamic response functions (HRFs), each describing the effect of a mental stimulus over time. We also provide systematic methods for constructing optimal and very efficient designs, and show that fMRI designs obtained by relabeling the symbols of m-sequences can be very efficient in comparing the HRFs.

AB - This article concerns optimal experimental designs for neuroimaging studies in which the pioneering functional magnetic resonance imaging (fMRI) technology is used to investigate functions of the human brain. We develop analytical results for identifying designs that allow precise estimates of the contrasts between hemodynamic response functions (HRFs), each describing the effect of a mental stimulus over time. We also provide systematic methods for constructing optimal and very efficient designs, and show that fMRI designs obtained by relabeling the symbols of m-sequences can be very efficient in comparing the HRFs.

KW - Circulant orthogonal array

KW - De Bruijn sequence

KW - Hadamard sequence

KW - Schur optimality

KW - Type 1 criterion

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DO - 10.1016/j.jspi.2016.09.005

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SP - 71

EP - 80

JO - Journal of Statistical Planning and Inference

JF - Journal of Statistical Planning and Inference

ER -

Optimal and efficient designs for functional brain imaging experiments

Abstract

Keywords

ASJC Scopus subject areas

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