Parasite potpourri: Toxoplasma gondii lineage tracing in vivo

Anita A. Koshy

doi:10.1016/j.pt.2022.10.002

Parasite potpourri: Toxoplasma gondii lineage tracing in vivo

Research output: Contribution to journal › Short survey › peer-review

Abstract

Using a CRISPR/Cas9-based method, Wincott et al. generated a stable, complex Toxoplasma gondii population composed of 96 barcoded clonal lineages. By tracking the population structure in vivo, they determine that – contrary to expectations – the pathway to infecting the brain is widely permissive for T. gondii.

Original language	English (US)
Pages (from-to)	1026-1027
Number of pages	2
Journal	Trends in Parasitology
Volume	38
Issue number	12
DOIs	https://doi.org/10.1016/j.pt.2022.10.002
State	Published - Dec 2022

Keywords

Toxoplasma gondii
blood–brain barrier
dissemination
genetic bottleneck
molecular barcode

ASJC Scopus subject areas

Parasitology
Infectious Diseases

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10.1016/j.pt.2022.10.002

Cite this

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title = "Parasite potpourri: Toxoplasma gondii lineage tracing in vivo",

abstract = "Using a CRISPR/Cas9-based method, Wincott et al. generated a stable, complex Toxoplasma gondii population composed of 96 barcoded clonal lineages. By tracking the population structure in vivo, they determine that – contrary to expectations – the pathway to infecting the brain is widely permissive for T. gondii.",

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author = "Koshy, {Anita A.}",

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year = "2022",

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AU - Koshy, Anita A.

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AB - Using a CRISPR/Cas9-based method, Wincott et al. generated a stable, complex Toxoplasma gondii population composed of 96 barcoded clonal lineages. By tracking the population structure in vivo, they determine that – contrary to expectations – the pathway to infecting the brain is widely permissive for T. gondii.

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KW - blood–brain barrier

KW - dissemination

KW - genetic bottleneck

KW - molecular barcode

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Parasite potpourri: Toxoplasma gondii lineage tracing in vivo

Abstract

Keywords

ASJC Scopus subject areas

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