Perspective on taxonomic classification of uncultivated viruses

Bas E. Dutilh; Arvind Varsani; Yigang Tong; Peter Simmonds; Sead Sabanadzovic; Luisa Rubino; Simon Roux; Alejandro Reyes Muñoz; Cédric Lood; Elliot J. Lefkowitz; Jens H. Kuhn; Mart Krupovic; Robert A. Edwards; J. Rodney Brister; Evelien M. Adriaenssens; Matthew B. Sullivan

doi:10.1016/j.coviro.2021.10.011

Perspective on taxonomic classification of uncultivated viruses

Bas E. Dutilh, Arvind Varsani, Yigang Tong, Peter Simmonds, Sead Sabanadzovic, Luisa Rubino, Simon Roux, Alejandro Reyes Muñoz, Cédric Lood, Elliot J. Lefkowitz, Jens H. Kuhn, Mart Krupovic, Robert A. Edwards, J. Rodney Brister, Evelien M. Adriaenssens, Matthew B. Sullivan

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Abstract

Historically, virus taxonomy has been limited to describing viruses that were readily cultivated in the laboratory or emerging in natural biomes. Metagenomic analyses, single-particle sequencing, and database mining efforts have yielded new sequence data on an astounding number of previously unknown viruses. As metagenomes are relatively free of biases, these data provide an unprecedented insight into the vastness of the virosphere, but to properly value the extent of this diversity it is critical that the viruses are taxonomically classified. Inclusion of uncultivated viruses has already improved the process as well as the understanding of the taxa, viruses, and their evolutionary relationships. The continuous development and testing of computational tools will be required to maintain a dynamic virus taxonomy that can accommodate the new discoveries.

Original language	English (US)
Pages (from-to)	207-215
Number of pages	9
Journal	Current opinion in virology
Volume	51
DOIs	https://doi.org/10.1016/j.coviro.2021.10.011
State	Published - Dec 2021

ASJC Scopus subject areas

Virology

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10.1016/j.coviro.2021.10.011

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Dutilh, B. E., Varsani, A., Tong, Y., Simmonds, P., Sabanadzovic, S., Rubino, L., Roux, S., Muñoz, A. R., Lood, C., Lefkowitz, E. J., Kuhn, J. H., Krupovic, M., Edwards, R. A., Brister, J. R., Adriaenssens, E. M., & Sullivan, M. B. (2021). Perspective on taxonomic classification of uncultivated viruses. Current opinion in virology, 51, 207-215. https://doi.org/10.1016/j.coviro.2021.10.011

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title = "Perspective on taxonomic classification of uncultivated viruses",

abstract = "Historically, virus taxonomy has been limited to describing viruses that were readily cultivated in the laboratory or emerging in natural biomes. Metagenomic analyses, single-particle sequencing, and database mining efforts have yielded new sequence data on an astounding number of previously unknown viruses. As metagenomes are relatively free of biases, these data provide an unprecedented insight into the vastness of the virosphere, but to properly value the extent of this diversity it is critical that the viruses are taxonomically classified. Inclusion of uncultivated viruses has already improved the process as well as the understanding of the taxa, viruses, and their evolutionary relationships. The continuous development and testing of computational tools will be required to maintain a dynamic virus taxonomy that can accommodate the new discoveries.",

author = "Dutilh, {Bas E.} and Arvind Varsani and Yigang Tong and Peter Simmonds and Sead Sabanadzovic and Luisa Rubino and Simon Roux and Mu{\~n}oz, {Alejandro Reyes} and C{\'e}dric Lood and Lefkowitz, {Elliot J.} and Kuhn, {Jens H.} and Mart Krupovic and Edwards, {Robert A.} and Brister, {J. Rodney} and Adriaenssens, {Evelien M.} and Sullivan, {Matthew B.}",

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year = "2021",

month = dec,

doi = "10.1016/j.coviro.2021.10.011",

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AU - Dutilh, Bas E.

AU - Varsani, Arvind

AU - Tong, Yigang

AU - Simmonds, Peter

AU - Sabanadzovic, Sead

AU - Rubino, Luisa

AU - Roux, Simon

AU - Muñoz, Alejandro Reyes

AU - Lood, Cédric

AU - Lefkowitz, Elliot J.

AU - Kuhn, Jens H.

AU - Krupovic, Mart

AU - Edwards, Robert A.

AU - Brister, J. Rodney

AU - Adriaenssens, Evelien M.

AU - Sullivan, Matthew B.

PY - 2021/12

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N2 - Historically, virus taxonomy has been limited to describing viruses that were readily cultivated in the laboratory or emerging in natural biomes. Metagenomic analyses, single-particle sequencing, and database mining efforts have yielded new sequence data on an astounding number of previously unknown viruses. As metagenomes are relatively free of biases, these data provide an unprecedented insight into the vastness of the virosphere, but to properly value the extent of this diversity it is critical that the viruses are taxonomically classified. Inclusion of uncultivated viruses has already improved the process as well as the understanding of the taxa, viruses, and their evolutionary relationships. The continuous development and testing of computational tools will be required to maintain a dynamic virus taxonomy that can accommodate the new discoveries.

AB - Historically, virus taxonomy has been limited to describing viruses that were readily cultivated in the laboratory or emerging in natural biomes. Metagenomic analyses, single-particle sequencing, and database mining efforts have yielded new sequence data on an astounding number of previously unknown viruses. As metagenomes are relatively free of biases, these data provide an unprecedented insight into the vastness of the virosphere, but to properly value the extent of this diversity it is critical that the viruses are taxonomically classified. Inclusion of uncultivated viruses has already improved the process as well as the understanding of the taxa, viruses, and their evolutionary relationships. The continuous development and testing of computational tools will be required to maintain a dynamic virus taxonomy that can accommodate the new discoveries.

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DO - 10.1016/j.coviro.2021.10.011

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SN - 1879-6257

VL - 51

SP - 207

EP - 215

JO - Current opinion in virology

JF - Current opinion in virology

ER -

Perspective on taxonomic classification of uncultivated viruses

Abstract

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