TY - JOUR
T1 - Perspectives on whole-organ assembly
T2 - Moving toward transplantation on demand
AU - Soto-Gutierrez, Alejandro
AU - Wertheim, Jason A.
AU - Ott, Harald C.
AU - Gilbert, Thomas W.
PY - 2012/11/1
Y1 - 2012/11/1
N2 - There is an ever-growing demand for transplantable organs to replace acute and chronically damaged tissues. This demand cannot be met by the currently available donor organs. Efforts to provide an alternative source have led to the development of organ engineering, a discipline that combines cell biology, tissue engineering, and cell/organ transplantation. Over the last several years, engineered organs have been implanted into rodent recipients and have shown modest function. In this article, we summarize the most recent advances in this field and provide a perspective on the challenges of translating this promising new technology into a proven regenerative therapy.
AB - There is an ever-growing demand for transplantable organs to replace acute and chronically damaged tissues. This demand cannot be met by the currently available donor organs. Efforts to provide an alternative source have led to the development of organ engineering, a discipline that combines cell biology, tissue engineering, and cell/organ transplantation. Over the last several years, engineered organs have been implanted into rodent recipients and have shown modest function. In this article, we summarize the most recent advances in this field and provide a perspective on the challenges of translating this promising new technology into a proven regenerative therapy.
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U2 - https://doi.org/10.1172/JCI61974
DO - https://doi.org/10.1172/JCI61974
M3 - Review article
C2 - 23114604
SN - 0021-9738
VL - 122
SP - 3817
EP - 3823
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 11
ER -