Phenotypic and functional stages in the intrathymic development of αβ T cells

Janko Nikolić-Žugić

doi:10.1016/0167-5699(91)90160-U

Phenotypic and functional stages in the intrathymic development of αβ T cells

Janko Nikolić-Žugić

Research output: Contribution to journal › Review article › peer-review

182 Scopus citations

Abstract

The thymus is the main site o f T-cell maturation. On arrival in the thymus, CD8-CD4- double-negative (DN) T-cell precursors undergo extensive gene rearrangement, phenotypic alteration and biochemical modi fication to yield the population of thymocytes that undergoes intrathymic selection. The selected mature thymocytes then go on to seed the periphery. In this article Janko Nikolić-Žugić discusses the labyrinthine development that constitutes αβ T-cell maturation and selection.

Original language	English (US)
Pages (from-to)	65-70
Number of pages	6
Journal	Immunology Today
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/0167-5699(91)90160-U
State	Published - Feb 1991

ASJC Scopus subject areas

Immunology

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10.1016/0167-5699(91)90160-U

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@article{32598d7f11874fc1b004749d104a89c8,

title = "Phenotypic and functional stages in the intrathymic development of αβ T cells",

abstract = "The thymus is the main site o f T-cell maturation. On arrival in the thymus, CD8-CD4- double-negative (DN) T-cell precursors undergo extensive gene rearrangement, phenotypic alteration and biochemical modi fication to yield the population of thymocytes that undergoes intrathymic selection. The selected mature thymocytes then go on to seed the periphery. In this article Janko Nikoli{\'c}-{\v Z}ugi{\'c} discusses the labyrinthine development that constitutes αβ T-cell maturation and selection.",

author = "Janko Nikoli{\'c}-{\v Z}ugi{\'c}",

note = "Funding Information: The author wishes to thank F.R. Carbone for helpful discussion, M.J. Bevan for continuous support, M.J. Bevan and J. Sprent for critical review of the manuscript, and H.L. Brewer and A. Kennard for secretarial assistance. This work was funded in part by NIH grant CA25803.",

year = "1991",

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doi = "10.1016/0167-5699(91)90160-U",

language = "English (US)",

volume = "12",

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journal = "Immunology Today",

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T1 - Phenotypic and functional stages in the intrathymic development of αβ T cells

AU - Nikolić-Žugić, Janko

N1 - Funding Information: The author wishes to thank F.R. Carbone for helpful discussion, M.J. Bevan for continuous support, M.J. Bevan and J. Sprent for critical review of the manuscript, and H.L. Brewer and A. Kennard for secretarial assistance. This work was funded in part by NIH grant CA25803.

PY - 1991/2

Y1 - 1991/2

N2 - The thymus is the main site o f T-cell maturation. On arrival in the thymus, CD8-CD4- double-negative (DN) T-cell precursors undergo extensive gene rearrangement, phenotypic alteration and biochemical modi fication to yield the population of thymocytes that undergoes intrathymic selection. The selected mature thymocytes then go on to seed the periphery. In this article Janko Nikolić-Žugić discusses the labyrinthine development that constitutes αβ T-cell maturation and selection.

AB - The thymus is the main site o f T-cell maturation. On arrival in the thymus, CD8-CD4- double-negative (DN) T-cell precursors undergo extensive gene rearrangement, phenotypic alteration and biochemical modi fication to yield the population of thymocytes that undergoes intrathymic selection. The selected mature thymocytes then go on to seed the periphery. In this article Janko Nikolić-Žugić discusses the labyrinthine development that constitutes αβ T-cell maturation and selection.

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U2 - 10.1016/0167-5699(91)90160-U

DO - 10.1016/0167-5699(91)90160-U

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EP - 70

JO - Immunology Today

JF - Immunology Today

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ER -

Phenotypic and functional stages in the intrathymic development of αβ T cells

Abstract

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