Polymer-drug conjugates: Manipulation of drug delivery kinetics

Colin G. Pitt; Jason Wertheim; C. T. Wang; Subodh S. Shah

doi:10.1002/masy.19971230122

Polymer-drug conjugates: Manipulation of drug delivery kinetics

Colin G. Pitt, Jason Wertheim, C. T. Wang, Subodh S. Shah

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Three methods of manipulating the kinetics of hydrolysis of polymer conjugates were evaluated. It was demonstrated that either first-order, zero-order or S-shaped kinetic profiles could be achieved by systematic changes in the chemical composition of several series of model side-chain substituted polyacrylates. The changes in kinetics were shown to arise from an increase in the rate constant during solvolysis, resulting from predictable changes in either the water content, secondary structure, or LCST of the polymer conjugate.

Original language	English (US)
Pages (from-to)	225-234
Number of pages	10
Journal	Macromolecular Symposia
Volume	123
DOIs	https://doi.org/10.1002/masy.19971230122
State	Published - Sep 1997
Externally published	Yes

ASJC Scopus subject areas

Condensed Matter Physics
Organic Chemistry
Polymers and Plastics
Materials Chemistry

Access to Document

10.1002/masy.19971230122

Cite this

@article{eb801ca22cdc4f34a11ab0018b0db4ce,

title = "Polymer-drug conjugates: Manipulation of drug delivery kinetics",

abstract = "Three methods of manipulating the kinetics of hydrolysis of polymer conjugates were evaluated. It was demonstrated that either first-order, zero-order or S-shaped kinetic profiles could be achieved by systematic changes in the chemical composition of several series of model side-chain substituted polyacrylates. The changes in kinetics were shown to arise from an increase in the rate constant during solvolysis, resulting from predictable changes in either the water content, secondary structure, or LCST of the polymer conjugate.",

author = "Pitt, {Colin G.} and Jason Wertheim and Wang, {C. T.} and Shah, {Subodh S.}",

year = "1997",

month = sep,

doi = "10.1002/masy.19971230122",

language = "English (US)",

volume = "123",

pages = "225--234",

journal = "Macromolecular Symposia",

issn = "1022-1360",

publisher = "Wiley-VCH Verlag",

}

TY - JOUR

T1 - Polymer-drug conjugates

T2 - Manipulation of drug delivery kinetics

AU - Pitt, Colin G.

AU - Wertheim, Jason

AU - Wang, C. T.

AU - Shah, Subodh S.

PY - 1997/9

Y1 - 1997/9

N2 - Three methods of manipulating the kinetics of hydrolysis of polymer conjugates were evaluated. It was demonstrated that either first-order, zero-order or S-shaped kinetic profiles could be achieved by systematic changes in the chemical composition of several series of model side-chain substituted polyacrylates. The changes in kinetics were shown to arise from an increase in the rate constant during solvolysis, resulting from predictable changes in either the water content, secondary structure, or LCST of the polymer conjugate.

AB - Three methods of manipulating the kinetics of hydrolysis of polymer conjugates were evaluated. It was demonstrated that either first-order, zero-order or S-shaped kinetic profiles could be achieved by systematic changes in the chemical composition of several series of model side-chain substituted polyacrylates. The changes in kinetics were shown to arise from an increase in the rate constant during solvolysis, resulting from predictable changes in either the water content, secondary structure, or LCST of the polymer conjugate.

UR - http://www.scopus.com/inward/record.url?scp=0642305093&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0642305093&partnerID=8YFLogxK

U2 - 10.1002/masy.19971230122

DO - 10.1002/masy.19971230122

M3 - Article

SN - 1022-1360

VL - 123

SP - 225

EP - 234

JO - Macromolecular Symposia

JF - Macromolecular Symposia

ER -

Polymer-drug conjugates: Manipulation of drug delivery kinetics

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this