Post-acute psychological effects of classical serotonergic psychedelics: A systematic review and meta-analysis

Simon B. Goldberg; Benjamin Shechet; Christopher R. Nicholas; Chi Wing Ng; Geetanjali Deole; Zhuofan Chen; Charles L. Raison

doi:10.1017/S003329172000389X

Post-acute psychological effects of classical serotonergic psychedelics: A systematic review and meta-analysis

Simon B. Goldberg, Benjamin Shechet, Christopher R. Nicholas, Chi Wing Ng, Geetanjali Deole, Zhuofan Chen, Charles L. Raison

Psychiatry

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

Background Scientific interest in the therapeutic effects of classical psychedelics has increased in the past two decades. The psychological effects of these substances outside the period of acute intoxication have not been fully characterized. This study aimed to: (1) quantify the effects of psilocybin, ayahuasca, and lysergic acid diethylamide (LSD) on psychological outcomes in the post-acute period; (2) test moderators of these effects; and (3) evaluate adverse effects and risk of bias.

Original language	English (US)
Journal	Psychological Medicine
DOIs	https://doi.org/10.1017/S003329172000389X
State	Accepted/In press - 2020

Keywords

Anxiety
LSD
ayahuasca
depression
meta-analysis
psilocybin
psychedelics
psychological effects

ASJC Scopus subject areas

Applied Psychology
Psychiatry and Mental health

Access to Document

10.1017/S003329172000389X

Cite this

@article{2b7bbae97be14eb182c5624468739e49,

title = "Post-acute psychological effects of classical serotonergic psychedelics: A systematic review and meta-analysis",

abstract = "Background Scientific interest in the therapeutic effects of classical psychedelics has increased in the past two decades. The psychological effects of these substances outside the period of acute intoxication have not been fully characterized. This study aimed to: (1) quantify the effects of psilocybin, ayahuasca, and lysergic acid diethylamide (LSD) on psychological outcomes in the post-acute period; (2) test moderators of these effects; and (3) evaluate adverse effects and risk of bias.",

keywords = "Anxiety, LSD, ayahuasca, depression, meta-analysis, psilocybin, psychedelics, psychological effects",

author = "Goldberg, {Simon B.} and Benjamin Shechet and Nicholas, {Christopher R.} and Ng, {Chi Wing} and Geetanjali Deole and Zhuofan Chen and Raison, {Charles L.}",

note = "Publisher Copyright: Copyright {\textcopyright} The Author(s), 2020. Published by Cambridge University Press.",

year = "2020",

doi = "10.1017/S003329172000389X",

language = "English (US)",

journal = "Psychological Medicine",

issn = "0033-2917",

publisher = "Cambridge University Press",

}

TY - JOUR

T1 - Post-acute psychological effects of classical serotonergic psychedelics

T2 - A systematic review and meta-analysis

AU - Goldberg, Simon B.

AU - Shechet, Benjamin

AU - Nicholas, Christopher R.

AU - Ng, Chi Wing

AU - Deole, Geetanjali

AU - Chen, Zhuofan

AU - Raison, Charles L.

PY - 2020

Y1 - 2020

N2 - Background Scientific interest in the therapeutic effects of classical psychedelics has increased in the past two decades. The psychological effects of these substances outside the period of acute intoxication have not been fully characterized. This study aimed to: (1) quantify the effects of psilocybin, ayahuasca, and lysergic acid diethylamide (LSD) on psychological outcomes in the post-acute period; (2) test moderators of these effects; and (3) evaluate adverse effects and risk of bias.

AB - Background Scientific interest in the therapeutic effects of classical psychedelics has increased in the past two decades. The psychological effects of these substances outside the period of acute intoxication have not been fully characterized. This study aimed to: (1) quantify the effects of psilocybin, ayahuasca, and lysergic acid diethylamide (LSD) on psychological outcomes in the post-acute period; (2) test moderators of these effects; and (3) evaluate adverse effects and risk of bias.

KW - Anxiety

KW - LSD

KW - ayahuasca

KW - depression

KW - meta-analysis

KW - psilocybin

KW - psychedelics

KW - psychological effects

UR - http://www.scopus.com/inward/record.url?scp=85095814303&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85095814303&partnerID=8YFLogxK

U2 - 10.1017/S003329172000389X

DO - 10.1017/S003329172000389X

M3 - Review article

C2 - 33143790

SN - 0033-2917

JO - Psychological Medicine

JF - Psychological Medicine

ER -

Post-acute psychological effects of classical serotonergic psychedelics: A systematic review and meta-analysis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this