TY - GEN
T1 - Preliminary investigation of design parameters of an innovative multi-pinhole system dedicated to brain SPECT imaging
AU - Auer, Benjamin
AU - Beenhouwer, Jan De
AU - Kalluri, Kesava
AU - Goding, Justin C.
AU - Furenlid, Lars R.
AU - King, Michael A.
N1 - Funding Information: Research reported in this publication was supported by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health under Award Number R01 EB022521. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: © 2018 IEEE.
PY - 2018/11
Y1 - 2018/11
N2 - Collimator penetration, down-scatter related to 123I high energy photons, and scatter within detectors can significantly degrade the imaging performance of any system. Precise selection of pinhole and collimator parameters using simulation studies has the potential to considerably reduce these effects. This type of investigation, thus represents an essential step in system development. An innovative multi-pinhole system, AdaptiSPECT-C, dedicated to clinical brain SPECT imaging, is currently under development at the universities of Massachusetts and Arizona. The aim of this work was to determine the system parameters which considerably improve AdaptiSPECT- C imaging performance for the criteria of sensitivity and relative amounts of scatter and penetration. A 20 mm thick, tungsten alloy collimator leads to the best trade-off between performance and price in case of 123I imaging. Tungsten alloy provided performance relatively close to that of gold in terms of stopping power as compared to lead alloy. A pinhole center distance of 0.5 cm to the aperture entry port led to the best compromise for locating the aperture within the aperture plate in terms of sensitivity and relative amounts of scatter and penetration.
AB - Collimator penetration, down-scatter related to 123I high energy photons, and scatter within detectors can significantly degrade the imaging performance of any system. Precise selection of pinhole and collimator parameters using simulation studies has the potential to considerably reduce these effects. This type of investigation, thus represents an essential step in system development. An innovative multi-pinhole system, AdaptiSPECT-C, dedicated to clinical brain SPECT imaging, is currently under development at the universities of Massachusetts and Arizona. The aim of this work was to determine the system parameters which considerably improve AdaptiSPECT- C imaging performance for the criteria of sensitivity and relative amounts of scatter and penetration. A 20 mm thick, tungsten alloy collimator leads to the best trade-off between performance and price in case of 123I imaging. Tungsten alloy provided performance relatively close to that of gold in terms of stopping power as compared to lead alloy. A pinhole center distance of 0.5 cm to the aperture entry port led to the best compromise for locating the aperture within the aperture plate in terms of sensitivity and relative amounts of scatter and penetration.
KW - I SPECT imaging
KW - Optimization study
KW - effects degrading imaging performance
KW - next-generation clinical system
UR - https://www.scopus.com/pages/publications/85073123597
UR - https://www.scopus.com/pages/publications/85073123597#tab=citedBy
U2 - 10.1109/NSSMIC.2018.8824691
DO - 10.1109/NSSMIC.2018.8824691
M3 - Conference contribution
T3 - 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018 - Proceedings
BT - 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018 - Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018
Y2 - 10 November 2018 through 17 November 2018
ER -