Prognostic Factors for Chronic Lymphocytic Leukemia

Christopher Chen; Soham Puvvada

doi:10.1007/s11899-015-0294-x

Prognostic Factors for Chronic Lymphocytic Leukemia

Christopher Chen, Soham Puvvada

Medicine

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

As novel strategies for treatment and prognostication of chronic lymphocytic leukemia (CLL) evolve, the traditional Rai and Binet systems can now be updated with more modern prognostic markers. This is a review of the latest articles which combine studies from major CLL centers to summarize major prognostic factors for patients diagnosed with CLL. The prognostic information can be categorized into three categories: genetic abnormalities which include 17p, 11q, and immunoglobulin heavy chain variable (IGHV) abnormalities; biochemical abnormalities and cell surface markers which include serum thymidine kinase, β-2-microglobulin, CD49d, CD38, and ZAP-70 levels; and patient characteristics which include sex, age, and performance status.

Original language	English (US)
Pages (from-to)	37-42
Number of pages	6
Journal	Current Hematologic Malignancy Reports
Volume	11
Issue number	1
DOIs	https://doi.org/10.1007/s11899-015-0294-x
State	Published - Feb 1 2016

Keywords

Chronic lymphocytic leukemia
Prognostication
Treatment

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1007/s11899-015-0294-x

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title = "Prognostic Factors for Chronic Lymphocytic Leukemia",

abstract = "As novel strategies for treatment and prognostication of chronic lymphocytic leukemia (CLL) evolve, the traditional Rai and Binet systems can now be updated with more modern prognostic markers. This is a review of the latest articles which combine studies from major CLL centers to summarize major prognostic factors for patients diagnosed with CLL. The prognostic information can be categorized into three categories: genetic abnormalities which include 17p, 11q, and immunoglobulin heavy chain variable (IGHV) abnormalities; biochemical abnormalities and cell surface markers which include serum thymidine kinase, β-2-microglobulin, CD49d, CD38, and ZAP-70 levels; and patient characteristics which include sex, age, and performance status.",

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AU - Puvvada, Soham

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AB - As novel strategies for treatment and prognostication of chronic lymphocytic leukemia (CLL) evolve, the traditional Rai and Binet systems can now be updated with more modern prognostic markers. This is a review of the latest articles which combine studies from major CLL centers to summarize major prognostic factors for patients diagnosed with CLL. The prognostic information can be categorized into three categories: genetic abnormalities which include 17p, 11q, and immunoglobulin heavy chain variable (IGHV) abnormalities; biochemical abnormalities and cell surface markers which include serum thymidine kinase, β-2-microglobulin, CD49d, CD38, and ZAP-70 levels; and patient characteristics which include sex, age, and performance status.

KW - Chronic lymphocytic leukemia

KW - Prognostication

KW - Treatment

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Prognostic Factors for Chronic Lymphocytic Leukemia

Abstract

Keywords

ASJC Scopus subject areas

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