Protein promoting vibrations in enzyme catalysis - A conserved evolutionary motif

Joshua S. Mincer; Steven D. Schwartz

doi:10.1021/pr025590

Protein promoting vibrations in enzyme catalysis - A conserved evolutionary motif

Joshua S. Mincer, Steven D. Schwartz

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

A computational method to identify residues important in creating a protein promoting vibration (PPV) in enzymes was previously developed and applied to horse liver alcohol dehydrogenase (HLADH), resulting in the identification of eight important residues. From these residues, we define a sequence motif, the PPV generating sequence, and find it to be unique and general to a larger group of alcohol dehydrogenases from diverse sources, demonstrating that nature has selected for the PPV generating sequence.

Original language	English (US)
Pages (from-to)	437-439
Number of pages	3
Journal	Journal of Proteome Research
Volume	2
Issue number	4
DOIs	https://doi.org/10.1021/pr025590
State	Published - Jul 2003

Keywords

Alcohol dehydrogenase
Computational algorithms
Enzyme catalysis
Molecular dynamics
Multiple alignment
Promoting vibration
Protein design
Protein dynamics
Quantum tunneling
Sequence homology

ASJC Scopus subject areas

Biochemistry
General Chemistry

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10.1021/pr025590

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abstract = "A computational method to identify residues important in creating a protein promoting vibration (PPV) in enzymes was previously developed and applied to horse liver alcohol dehydrogenase (HLADH), resulting in the identification of eight important residues. From these residues, we define a sequence motif, the PPV generating sequence, and find it to be unique and general to a larger group of alcohol dehydrogenases from diverse sources, demonstrating that nature has selected for the PPV generating sequence.",

keywords = "Alcohol dehydrogenase, Computational algorithms, Enzyme catalysis, Molecular dynamics, Multiple alignment, Promoting vibration, Protein design, Protein dynamics, Quantum tunneling, Sequence homology",

author = "Mincer, {Joshua S.} and Schwartz, {Steven D.}",

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AU - Schwartz, Steven D.

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AB - A computational method to identify residues important in creating a protein promoting vibration (PPV) in enzymes was previously developed and applied to horse liver alcohol dehydrogenase (HLADH), resulting in the identification of eight important residues. From these residues, we define a sequence motif, the PPV generating sequence, and find it to be unique and general to a larger group of alcohol dehydrogenases from diverse sources, demonstrating that nature has selected for the PPV generating sequence.

KW - Alcohol dehydrogenase

KW - Computational algorithms

KW - Enzyme catalysis

KW - Molecular dynamics

KW - Multiple alignment

KW - Promoting vibration

KW - Protein design

KW - Protein dynamics

KW - Quantum tunneling

KW - Sequence homology

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EP - 439

JO - Journal of Proteome Research

JF - Journal of Proteome Research

IS - 4

ER -

Protein promoting vibrations in enzyme catalysis - A conserved evolutionary motif

Abstract

Keywords

ASJC Scopus subject areas

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