Random and site-specific mutagenesis of the Helicobacter pylori ferric uptake regulator provides insight into Fur structure-function relationships

Keyphrases

• Helicobacter Pylori (H. pylori) 100%
• Site-directed mutagenesis 100%
• Structure Function 100%
• Ferric Uptake Regulator 100%
• Gene Expression 11%
• Apo Form 11%
• Metal-binding Site 11%
• Purified Proteins 5%
• Targeted Sequencing 5%
• Amino Acid Residues 5%
• DNA Binding 5%
• Secondary Structure 5%
• Transcriptional Analysis 5%
• Manganese 5%
• Distinct Roles 5%
• Structural Metals 5%
• Oligomerization 5%
• Bound Form 5%
• Circular Dichroism Spectroscopy 5%
• Fluorescence Anisotropy 5%
• Gastric mucosa 5%
• N-terminal Extension 5%
• Iron Binding 5%
• Atomic Absorption Spectrophotometry 5%
• Global Regulator 5%
• Regulatory Phenotype 5%

Biochemistry, Genetics and Molecular Biology

• Helicobacter Pylori 100%
• Site-Directed Mutagenesis 100%
• Structure Activity Relation 100%
• Ferric Uptake Regulator 100%
• Gene Expression 11%
• Binding Site 11%
• N-Terminus 11%
• Metal Binding 11%
• Amino Acids 5%
• Wild Type 5%
• DNA Binding 5%
• Protein Secondary Structure 5%
• Cross-Link 5%
• Oligomerization 5%
• Stomach Mucosa 5%
• Atomic Absorption 5%
• Fluorescence Anisotropy 5%
• Circular Dichroism 5%
• Manganese 5%

Immunology and Microbiology

• Helicobacter Pylori 100%
• Site Directed Mutagenesis 100%
• Structure Activity Relation 100%
• Ferric Uptake Regulator 100%
• Gene Expression 11%
• Amino Terminal Sequence 11%
• Binding Site 11%
• Metal Binding 11%
• Wild Type 5%
• Cross Linking 5%
• DNA Binding 5%
• Protein Secondary Structure 5%
• Oligomerization 5%
• Anisotropy 5%
• Stomach Mucosa 5%
• Atomic Absorption Spectroscopy 5%
• Amino Acid 5%
• In Vitro 5%