Recent Advances in Real-Time Label-Free Detection of Small Molecules

Andy Chieng, Zijian Wan, Shaopeng Wang

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

The detection and analysis of small molecules, typically defined as molecules under 1000 Da, is of growing interest ranging from the development of small-molecule drugs and inhibitors to the sensing of toxins and biomarkers. However, due to challenges such as their small size and low mass, many biosensing technologies struggle to have the sensitivity and selectivity for the detection of small molecules. Notably, their small size limits the usage of labeled techniques that can change the properties of small-molecule analytes. Furthermore, the capability of real-time detection is highly desired for small-molecule biosensors’ application in diagnostics or screening. This review highlights recent advances in label-free real-time biosensing technologies utilizing different types of transducers to meet the growing demand for small-molecule detection.

Original languageEnglish (US)
Article number80
JournalBiosensors
Volume14
Issue number2
DOIs
StatePublished - Feb 2024

Keywords

  • biosensor
  • electrochemical transduction
  • label-free
  • optical transduction
  • piezoelectric transduction
  • real-time detection
  • small molecule

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biotechnology
  • Biomedical Engineering
  • Instrumentation
  • Engineering (miscellaneous)
  • Clinical Biochemistry

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