Reduction of PrPCin human cerebrospinal fluid after spinal cord injury

Anna Carnini; Steve Casha; V. Wee Yong; R. John Hurlbert; Janice E.A. Braun

doi:10.4161/pri.4.2.11756

Reduction of PrP^Cin human cerebrospinal fluid after spinal cord injury

Anna Carnini, Steve Casha, V. Wee Yong, R. John Hurlbert, Janice E.A. Braun

Neurosurgery

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

It has been estimated that cerebrospinal fluid (CSF) contains approximately 80 proteins that significantly increase or decrease in response to various clinical conditions. Here we have evaluated the CSF protein PrP^C (cellular prion protein) for possible increases or decreases following spinal cord injury. The physiological function of PrP^C is not yet completely understood; however, recent findings suggest that PrP^C may have neuroprotective properties. Our results show that CSF PrP^C is decreased in spinal cord injured patients 12 h following injury and is absent at 7 days. Given that normal PrP^C has been proposed to be neuroprotective, we speculate that the decrease in CSF PrP^C levels may influence neuronal cell survival following spinal cord injury.

Original language	English (US)
Pages (from-to)	80-86
Number of pages	7
Journal	Prion
Volume	4
Issue number	2
DOIs	https://doi.org/10.4161/pri.4.2.11756
State	Published - Apr 2010

Keywords

CSF
Crystallin domain
Hsp25
PrP
Spinal cord injury

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience
Cell Biology
Infectious Diseases

Access to Document

10.4161/pri.4.2.11756

Cite this

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title = "Reduction of PrPCin human cerebrospinal fluid after spinal cord injury",

abstract = "It has been estimated that cerebrospinal fluid (CSF) contains approximately 80 proteins that significantly increase or decrease in response to various clinical conditions. Here we have evaluated the CSF protein PrPC (cellular prion protein) for possible increases or decreases following spinal cord injury. The physiological function of PrPC is not yet completely understood; however, recent findings suggest that PrPC may have neuroprotective properties. Our results show that CSF PrPC is decreased in spinal cord injured patients 12 h following injury and is absent at 7 days. Given that normal PrPC has been proposed to be neuroprotective, we speculate that the decrease in CSF PrPC levels may influence neuronal cell survival following spinal cord injury.",

keywords = "CSF, Crystallin domain, Hsp25, PrP, Spinal cord injury",

author = "Anna Carnini and Steve Casha and Yong, {V. Wee} and Hurlbert, {R. John} and Braun, {Janice E.A.}",

note = "Funding Information: We thank Tatania Noskova and Claudia Silva for technical contributions. This work was funded by the Alberta Prion Research Institute. J.E.A.B. is an Alberta Heritage Research Foundation for Medical Research Senior Scholar.",

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AU - Braun, Janice E.A.

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