Reimagining C(sp3)–N bond formation via a HARC strategy

Michael S. Crocker; Reem Nsouli; Laura K.G. Ackerman-Biegasiewicz

doi:10.1016/j.chempr.2021.06.017

Reimagining C(sp³)–N bond formation via a HARC strategy

Michael S. Crocker
, Reem Nsouli
, Laura K.G. Ackerman-Biegasiewicz

Molecular Sciences, School of (SMS)

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Conventional N-alkylation methods have been limited to approaches with high energy barriers and low selectivity. In this issue of Chem, MacMillan and co-workers report an innovative halogen abstraction-radical capture (HARC) strategy via metallaphotoredox catalysis that couples strained and hindered alkyl halides with a diverse range of N-nucleophiles.

Original language	English (US)
Pages (from-to)	1688-1691
Number of pages	4
Journal	Chem
Volume	7
Issue number	7
DOIs	https://doi.org/10.1016/j.chempr.2021.06.017
State	Published - Jul 8 2021

ASJC Scopus subject areas

General Chemistry
Biochemistry
Environmental Chemistry
General Chemical Engineering
Biochemistry, medical
Materials Chemistry

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10.1016/j.chempr.2021.06.017

Cite this

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title = "Reimagining C(sp3)–N bond formation via a HARC strategy",

abstract = "Conventional N-alkylation methods have been limited to approaches with high energy barriers and low selectivity. In this issue of Chem, MacMillan and co-workers report an innovative halogen abstraction-radical capture (HARC) strategy via metallaphotoredox catalysis that couples strained and hindered alkyl halides with a diverse range of N-nucleophiles.",

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N2 - Conventional N-alkylation methods have been limited to approaches with high energy barriers and low selectivity. In this issue of Chem, MacMillan and co-workers report an innovative halogen abstraction-radical capture (HARC) strategy via metallaphotoredox catalysis that couples strained and hindered alkyl halides with a diverse range of N-nucleophiles.

AB - Conventional N-alkylation methods have been limited to approaches with high energy barriers and low selectivity. In this issue of Chem, MacMillan and co-workers report an innovative halogen abstraction-radical capture (HARC) strategy via metallaphotoredox catalysis that couples strained and hindered alkyl halides with a diverse range of N-nucleophiles.

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Reimagining C(sp³)–N bond formation via a HARC strategy

Abstract

ASJC Scopus subject areas

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