Relationship between the expression of surface markers and synthesis of immunoglobulin E by peripheral blood mononuclear cells under the influence of recombinant interleukin-4

R. G. Vasilov; L. K. Chelidze; Yu S. Lebedin; S. V. Chukanova; E. N. Tsytsikov; V. I. Pivnyuk

doi:10.1007/BF02446475

Relationship between the expression of surface markers and synthesis of immunoglobulin E by peripheral blood mononuclear cells under the influence of recombinant interleukin-4

R. G. Vasilov, L. K. Chelidze, Yu S. Lebedin, S. V. Chukanova, E. N. Tsytsikov, V. I. Pivnyuk

Research output: Contribution to journal › Article › peer-review

Abstract

The relationship between interleukin-4-induced synthesis of immunoglobulin E (IgE) by peripheral blood mononuclear cells of healthy donors and the expression of T- and B-cell surface differentiating markers is studied. It is demonstrated that the high level of IgE response on day 10 of culturing correlates with a higher level of expression of the T-cell activation markers HLA-DR and CD25 and a low level of expression of the low-affinity IgE receptor CD23 on the surface of B cells. Activation of T cells is interleukin-4-independent, since it occurs to an equal degree when these cells are cultured without interleukin-4.

Original language	English (US)
Pages (from-to)	1121-1125
Number of pages	5
Journal	Bulletin of Experimental Biology and Medicine
Volume	118
Issue number	4
DOIs	https://doi.org/10.1007/BF02446475
State	Published - Oct 1994

Keywords

immunoglobulin E
interleukin-4
surface antigens

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/BF02446475

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Vasilov, R. G., Chelidze, L. K., Lebedin, Y. S., Chukanova, S. V., Tsytsikov, E. N., & Pivnyuk, V. I. (1994). Relationship between the expression of surface markers and synthesis of immunoglobulin E by peripheral blood mononuclear cells under the influence of recombinant interleukin-4. Bulletin of Experimental Biology and Medicine, 118(4), 1121-1125. https://doi.org/10.1007/BF02446475

Relationship between the expression of surface markers and synthesis of immunoglobulin E by peripheral blood mononuclear cells under the influence of recombinant interleukin-4. / Vasilov, R. G.; Chelidze, L. K.; Lebedin, Yu S. et al.
In: Bulletin of Experimental Biology and Medicine, Vol. 118, No. 4, 10.1994, p. 1121-1125.

Research output: Contribution to journal › Article › peer-review

Vasilov, RG, Chelidze, LK, Lebedin, YS, Chukanova, SV, Tsytsikov, EN & Pivnyuk, VI 1994, 'Relationship between the expression of surface markers and synthesis of immunoglobulin E by peripheral blood mononuclear cells under the influence of recombinant interleukin-4', Bulletin of Experimental Biology and Medicine, vol. 118, no. 4, pp. 1121-1125. https://doi.org/10.1007/BF02446475

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abstract = "The relationship between interleukin-4-induced synthesis of immunoglobulin E (IgE) by peripheral blood mononuclear cells of healthy donors and the expression of T- and B-cell surface differentiating markers is studied. It is demonstrated that the high level of IgE response on day 10 of culturing correlates with a higher level of expression of the T-cell activation markers HLA-DR and CD25 and a low level of expression of the low-affinity IgE receptor CD23 on the surface of B cells. Activation of T cells is interleukin-4-independent, since it occurs to an equal degree when these cells are cultured without interleukin-4.",

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AU - Tsytsikov, E. N.

AU - Pivnyuk, V. I.

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Relationship between the expression of surface markers and synthesis of immunoglobulin E by peripheral blood mononuclear cells under the influence of recombinant interleukin-4

Abstract

Keywords

ASJC Scopus subject areas

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