@article{2b9c1d7671944c52a6778d9ac868e514,
title = "Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of αCaMKII inhibitory phosphorylation",
abstract = "Angelman syndrome (AS) is a severe neurological disorder characterized by mental retardation, motor dysfunction and epilepsy. We show that the molecular and cellular deficits of an AS mouse model can be rescued by introducing an additional mutation at the inhibitory phosphorylation site of αCaMKII. Moreover, these double mutants no longer show the behavioral deficits seen in AS mice, suggesting that these deficits are the direct result of increased inhibitory phosphorylation of αCaMKII.",
author = "{Van Woerden}, {Geeske M.} and Harris, {Karen D.} and Hojjati, {Mohammad Reza} and Gustin, {Richard M.} and Shenfeng Qiu and {De Avila Freire}, Rogerio and Jiang, {Yong Hui} and Ype Elgersma and Weeber, {Edwin J.}",
note = "Funding Information: The authors thank M. Elgersma and M. Aghadavoud Jolfaei for technical support. This work was supported by the Netherlands Organization for Scientific Research (NWO-ZonMW), Hersenstichting Nederland (HsN), Netherlands Epilepsy Fund and the Nina Foundation/Angelman Vereniging.",
year = "2007",
month = mar,
doi = "10.1038/nn1845",
language = "English (US)",
volume = "10",
pages = "280--282",
journal = "Nature neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "3",
}